S-adenosyl-L-methionine｜Huagongshe

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HCID 34756Erstellt: 27. Oktober 2026

S-adenosyl-L-methionine

13CH3-SAM · Methionine,active · S-ADENOSYLMETHIONINE · Adenosine Impurity 39 · S-(5'-Adenosyl)methionine · MEFKEPWMEQBLKI-AIRLBKTGSA-O · S-adenosylmethionine USP/EP/BP · Ademetionine 1,4-Butanedisulfonate Impurity 18 Monomer

https://huagongshe.com/de/chemical/34756

Molekülstruktur von S-adenosyl-L-methionine

Identifikatoren & physikalische Daten

CAS No.	485-80-3
Summenformel	C15H23N6O5S+
Durchschnittliche Molmasse	399,4 g/mol
Monoisotopische Masse	399,14451526 g/mol
SMILES	C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O
InChIKey	MEFKEPWMEQBLKI-AIRLBKTGSA-O
PubChem CID	34756
ChEMBL	CHEMBL224120
ChEBI	CHEBI:15414
DTXSID	DTXSID20110014

Chemische & physikalische Eigenschaften

XLogP	-3,5
Polarare Oberfläche (TPSA)	184
H-Brücken-Donoren	5
H-Brücken-Akzeptoren	10
Frei drehbare Bindungen	7
Schwere Atome	27
Formalladung	1
Komplexität	533
Arzneimittel	Pharmaceuticals -> Listed in ZINC15
LogP (Verteilungskoeffizient)	-5.3
Siedepunkt	78 °C
Physical Description	Solid
Collision Cross Section	185.6 Å² [M+H]+
InChIKey	QOWKLNSTGYYNGX-MDHPBGAINA-N
SMILES	C(O)(=O)[C@H](CCS(C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)N)N=C2)[C@H](O)[C@@H]1O)C)N \|&1:3,8,10,21,23,r\|

Sicherheit & Vorschriften

Expositionspfade	S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake.
Toxizitätsübersicht	S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.
Carcinogen Classification	No indication of carcinogenicity to humans (not listed by IARC).
Alarmwort	Warnung
Gefahrenhinweise	Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302