HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
11-Methoxy-5-methyl-1,3-dioxolo(4,5-b)acridin-10(5H)-one
Evoxanthine · 11-Methoxy-5-methyl-1,3-dioxolo[4,5-b]acridin-10(5H)-one · 1,3-Dioxolo[4,5-b]acridin-10(5H)-one, 11-methoxy-5-methyl-
Identifikatoren & physikalische Daten
| CAS No. | 477-82-7 |
|---|---|
| Summenformel | C16H13NO4 |
| Durchschnittliche Molmasse | 283,28 g/mol |
| Monoisotopische Masse | 283,0844579 g/mol |
| SMILES | COc1c2c(cc3c1c(=O)c1ccccc1n3C)OCO2 |
| InChIKey | ULBVHYNIDQSMFC-UHFFFAOYSA-N |
| PubChem CID | 348484 |
| DTXSID | DTXSID00324839 |
Chemische & physikalische Eigenschaften
| XLogP | 2,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 48 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 21 |
| Formalladung | 0 |
| Komplexität | 429 |
| Lagerbedingungen | Store at -20°C |
| Löslichkeit | Soluble in DMSO |
| Aggregatzustand | A solid |
Anwendungen & Verwendung
Beschreibung
Evoxanthine is an alkaloid that has been found in O. renieri and has antimalarial and anticancer activities. It is active against P. falciparum with an IC50 value of 67.6 μg/ml. Evoxanthine decreases proliferation of nine sensitive and drug-resistant cancer cell lines (IC50s = 6.11-80.99 μM).