Guanethidin

Dopom · C07036 · Eutensol · Abapresin · Octatensine · guanethidine · guanethidine USP/EP/BP · 2-[2-(azocan-1-yl)ethyl]guanidine

https://huagongshe.com/de/chemical/3518

Identifikatoren & physikalische Daten

CAS No.	55-65-2
Summenformel	C10H22N4
Durchschnittliche Molmasse	198,31 g/mol
Monoisotopische Masse	198,1844467 g/mol
SMILES	NC(N)=NCCN1CCCCCCC1
InChIKey	ACGDKVXYNVEAGU-UHFFFAOYSA-N
PubChem CID	3518
ChEMBL	CHEMBL765
ChEBI	CHEBI:5557
EC No.	200-241-3
DTXSID	DTXSID5023116
Lokaler Name	Guanethidin

Chemische & physikalische Eigenschaften

XLogP	0,5
Polarare Oberfläche (TPSA)	67,6
H-Brücken-Donoren	2
H-Brücken-Akzeptoren	2
Frei drehbare Bindungen	3
Schwere Atome	14
Formalladung	0
Komplexität	167
Arzneimittel	Pharmaceuticals -> Listed in ZINC15
LogP (Verteilungskoeffizient)	0.8
Löslichkeit	Very solubleWHITE, CRYSTALLINE POWDERSTRONG CHARACTERISTIC ODORSPARINGLY SOL IN WATERSLIGHTLY SOL IN ALCPRACTICALLY INSOL IN CHLOROFORM /SULFATE/VERY SOL IN H2OINSOL IN NONPOLAR SOLVENTS /MONOSULFATE/2.25e+00 g/L
Human Drugs	Pharmaceuticals
Endocrine Disruptors	Potential endocrine disrupting compound
Schmelzpunkt	276-281250 °C (sulfate salt)
Physical Description	Solid
Collision Cross Section	151.79 Å² [M+K]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
Other Experimental Properties	CRYSTALS FROM DIL ETHANOLMP 276-281 °C (DECOMP) /SULFATE/
Siedepunkt	325.64°C (rough estimate)
Dichte	0.9402 (rough estimate)
Brechungsindex	1.4910 (estimate)
Lagerbedingungen	Store at -20°C
pKa (Säurekonstante)	pKa 11.4 (Uncertain)

Sicherheit & Vorschriften

Toxizität
Weitere Sicherheitsinformationen	IMAP assessments - Guanidine, [2-(hexahydro-1(2H)-azocinyl)ethyl]-: Environment tier I assessment
Wechselwirkungen	MONOAMINE OXIDASE INHIBITORS HAVE BEEN REPORTED TO ANTAGONIZE ANTIHYPERTENSIVE EFFECTS OF GUANETHIDINE.TOPICALLY ADMIN GUANETHIDINE ENHANCES RESPONSE OF EYE TO TOPICALLY ADMIN PHENYLEPHRINE, RESULTING IN INCR MYDRIASIS.THIAZIDES ENHANCE ANTIHYPERTENSIVE ACTION OF GUANETHIDINE, ALLOWING DOSE OF GUANETHIDINE TO BE REDUCED & DECR INCIDENCE OF ADVERSE REACTIONS...ANTIHYPERTENSIVE ACTION OF GUANETHIDINE MAY BE BLOCKED BY DEXTROAMPHETAMINE & RELATED COMPDTHEREFORE, CONCURRENT USE OF THESE DRUGS SHOULD BE AVOIDED.For more Interactions (Complete) data for GUANETHIDINE (10 total), please visit the HSDB record page.
Human Toxicity Excerpts	SOME TENDENCY TO DIARRHEA IS ASSOC WITH GUANETHIDINE THERAPY IN HIGH PERCENTAGE OF CASES... INHIBITION OF EJACULATION IS COMMON, & IMPOTENCE MAY BE PSCHOGENIC AFTERMATH. ...CAN CAUSE SEVERE HYPERTENSIVE REACTIONS IN PT WITH PHEOCHROMOCYTOMA.HYPOTENSIVE EPISODES MAY BE ASSOC WITH SYMPTOMS OF CEREBRAL & MYOCARDIAL ISCHEMIA. ... GENERALIZED SUBJECTIVE "WEAKNESS" IS COMMON... FLUID RETENTION OCCURS & CAN LEAD TO EDEMA & RESISTANCE TO ANTIHYPERTENSIVE EFFECT IF DIURETIC IS NOT GIVEN CONCURRENTLY. ...CAN LEAD TO...HEART FAILURE IN PT WITH LIMITED CARDIAC RESERVE.MOST IMPORTANT COMPLICATION OF GUANETHIDINE THERAPY IS POSTURAL HYPOTENSIONIT IS MOST PROMINENT SHORTLY AFTER ARISING FROM SLEEP & MAY BE ACCENTUATED BY HOT WEATHER, ALCOHOL, OR EXERCISE.APPLICATION OF 5%-10% GUANETHIDINE SULFATE SOLN TO EYES OF PT HAS INDUCED SLIGHT MIOSIS, NOTICEABLE PTOSIS & HYPEREMIA FROM ANTIADRENERGIC ACTION. ... 50% OF PT WITH THYROID DYSFUNCTION & EXOPHTHALMOS HAVE DEVELOPED SUPERFICIAL CHANGES IN CORNEAL EPITHELIUM AFTER 1-8 WK OF APPLYING SOLN TWICE DAY. /SULFATE/For more Human Toxicity Excerpts (Complete) data for GUANETHIDINE (9 total), please visit the HSDB record page.
Drug Induced Liver Injury	Benchmark Dataset for the Liver Toxicity Knowledge Base (LTKB)guanethidineIsmelin®AntiadrenergicsNot Applicableno-DILI-concern

Anwendungen & Verwendung

Beschreibung

Guanethidine is used for severe hypertension when the use of the more generally accepted drugs turns out to be unsuccessful. It is a powerful, long-lasting antihypertensive drug; however, it affects a patient’s blood pressure only in the orthostatic position, and not when lying down. Guanethidine is a very powerful and long-lasting drug, and its action often lasts 2–3 days after its use has been stopped.

Verwenden

Guanethidine is used for severe hypertension, where use of more universally accepted drugs is not successful. It is a very powerful and long-lasting drug, and its effects last for 2–3 days after using it.

Verwenden

Antihypertensive.