HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 3545604Erstellt: 3. November 2026
3-[20-(2-Carboxyethyl)-9,14-bis(ethenyl)-5,10,15,19-tetramethyl-2,22,23,25-tetraza-1-stannaoctacyclo[11.9.1.11,8.13,21.02,6.016,23.018,22.011,25]pentacosa-3(24),4,6,8,10,12,14,16,18,20-decaen-4-yl]propanoic acid
SnPPIX · Nsc267099 · TINPROTOPORPHYRIN · Tin protoporphyrin I · tin protoporphyrin IX · TIN PROTOPORPHYRIN IX DICHLORIDE · Tin Protoporphyrin IX (chloride) · Tinprotoporphyrin IX,Tin protoporphyrin IX
https://huagongshe.com/de/chemical/3545604
Identifikatoren & physikalische Daten
| CAS No. | 14325-05-4 |
|---|
| Summenformel | C34H32N4O4Sn |
|---|
| Durchschnittliche Molmasse | 679,4 g/mol |
|---|
| Monoisotopische Masse | 680,144558 g/mol |
|---|
| SMILES | C=CC1=C(C)C2=Cc3c(C=C)c(C)c4[n]3[Sn][n]3c(c(C)c(CCC(=O)O)c3=CC3=NC(=C4)C(C)=C3CCC(=O)O)=CC1=N2 |
|---|
| InChIKey | YFPCUOXWZGYBEL-UHFFFAOYSA-L |
|---|
| PubChem CID | 3545604 |
|---|
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 107 |
|---|
| H-Brücken-Donoren | 2 |
|---|
| H-Brücken-Akzeptoren | 7 |
|---|
| Frei drehbare Bindungen | 8 |
|---|
| Schwere Atome | 43 |
|---|
| Formalladung | 0 |
|---|
| Komplexität | 1.660 |
|---|
| Lagerbedingungen | Store at RT |
|---|
| Löslichkeit | Soluble to 25 mM in 1eq. NaOH and to 5 mM in DMSO |
|---|
| Aggregatzustand | Dark red to violet solid. |
|---|
| Farbe | Brown to reddish brown |
|---|
Sicherheit & Vorschriften
| Alarmwort | Warnung |
|---|
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H315 |
|---|
Anwendungen & Verwendung
Verwenden
Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin . While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. TIN PROTOPORPHYRIN IX DICHLORIDE(SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.[Cayman Chemical]
![Molekülstruktur von 3-[20-(2-Carboxyethyl)-9,14-bis(ethenyl)-5,10,15,19-tetramethyl-2,22,23,25-tetraza-1-stannaoctacyclo[11.9.1.11,8.13,21.02,6.016,23.018,22.011,25]pentacosa-3(24),4,6,8,10,12,14,16,18,20-decaen-4-yl]propanoic acid](/img/chemical/3545604.png)