HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
SID 487795
NSC 617145 · SID 487795 · NSC-617145 · WRN inhibitor · NSC 617145, 10 mM in DMSO · (2,3-Propandiyl-bis(2,3-dichloro)maleimide · NSC617145 · 1,1′-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione
Identifikatoren & physikalische Daten
| CAS No. | 203115-63-3 |
|---|---|
| Summenformel | C13H10Cl4N2O4 |
| Durchschnittliche Molmasse | 400,04 g/mol |
| SMILES | CC(C)(CN1C(=O)C(Cl)=C(Cl)C1=O)CN1C(=O)C(Cl)=C(Cl)C1=O |
| InChIKey | PCOXPBOKDABARQ-UHFFFAOYSA-N |
| PubChem CID | 357621 |
| ChEMBL | CHEMBL1968672 |
| EC No. | 809-054-7 |
Chemische & physikalische Eigenschaften
| Siedepunkt | 451.5±45.0 °C(Predicted) |
|---|---|
| Dichte | 1.67±0.1 g/cm3(Predicted) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | DMSO: soluble3mg/mL, clear (warmed) |
| pKa (Säurekonstante) | -6.03±0.60(Predicted) |
| Aggregatzustand | powder |
| Farbe | white to light brown |
| InChI | 1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3 |
| InChIKey | PCOXPBOKDABARQ-UHFFFAOYSA-N |
| SMILES | ClC1=C(C(=O)N(C1=O)CC(CN2C(=O)C(=C(C2=O)Cl)Cl)(C)C)Cl |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36/37/39 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
Anwendungen & Verwendung
Verwenden
NSC 617145 is ahelicase inhibitor used in the treatment of Werner syndrome helicase and acts synergistically with Mitomycin C (M371900), an antitumor antibiotic. It is used as antineoplastic.