HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Heptaminol
heptaminol · 2-Heptanol, 6-amino-2-methyl- · Heptaminol API · TIMTEC-BB SBB004116 · 6-amino-2-methyl-2-heptano · 6-AMino-2-Methylheptan-2-ol · 6-Amino-2-methyl-2-heptanol · 2-Methyl-6-aminoheptane-2-ol
Identifikatoren & physikalische Daten
| CAS No. | 372-66-7 |
|---|---|
| Summenformel | C8H19NO |
| Durchschnittliche Molmasse | 145,24 g/mol |
| Monoisotopische Masse | 145,14666423 g/mol |
| SMILES | CC(N)CCCC(C)(C)O |
| InChIKey | LREQLEBVOXIEOM-UHFFFAOYSA-N |
| PubChem CID | 3590 |
| ChEMBL | CHEMBL2111076 |
| ChEBI | CHEBI:94362 |
| EC No. | 206-758-0 |
| DTXSID | DTXSID4048484 |
| Lokaler Name | Heptaminol |
Chemische & physikalische Eigenschaften
| XLogP | 0,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 46,3 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 91,3 |
| Human Drugs | Pharmaceuticals |
| Collision Cross Section | 132.54 Ų [M+H-H2O]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Schmelzpunkt | <25 °C |
| Siedepunkt | 115 °C (11.2515 mmHg) |
| Dichte | 0.895 |
| Brechungsindex | 1.455-1.457 |
| Lagerbedingungen | Refrigerator |
| Löslichkeit | DMSO (Slightly), Methanol (Slightly) |
| pKa (Säurekonstante) | 15.30±0.29(Predicted) |
| Aggregatzustand | Oily Liquid |
| Farbe | Clear colorless |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Skin Corr. 1B (100%) |
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)HeptaminolDILI PositiveDOI:10.1016/j.drudis.2019.09.022 |
| Zollcode | 29221985 |
| R-Sätze (R) | 34 |
| Gefahrensymbole | C |
| Sicherheitshinweise (S) | 45-36/37/39-26 |
Anwendungen & Verwendung
Beschreibung
Heptaminol is an aliphatic amine with cardiotonic and sympathomimetic activities. It decreases the amplitude of peak calcium currents by 30% in isolated guinea pig ventricular myocytes when used at a concentration of 100 μM. Heptaminol inhibits norepinephrine uptake and induces catecholamine release in primary bovine chromaffin cells. It increases blood pressure in cats when administered intravenously at a dose of 15 mg, an effect that can be blocked by reserpine .
Verwenden
vasodilator