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Acesulfam
ACESULFAME K · Ansaimi · Acesulfam · RARECHEM AM UC 0205 · SWEET ONE · ACESULFAME POTASSIUM SALT · Ansemi · SUNETTE
Identifikatoren & physikalische Daten
| CAS No. | 33665-90-6 |
|---|---|
| Summenformel | C4H5NO4S |
| Durchschnittliche Molmasse | 163,15 g/mol |
| Monoisotopische Masse | 162,99392881 g/mol |
| SMILES | CC1=CC(=O)NS(=O)(=O)O1 |
| InChIKey | YGCFIWIQZPHFLU-UHFFFAOYSA-N |
| PubChem CID | 36573 |
| ChEMBL | CHEMBL176687 |
| ChEBI | CHEBI:83501 |
| EC No. | 251-622-6 |
| DTXSID | DTXSID0048006 |
| Lokaler Name | Acesulfam |
Chemische & physikalische Eigenschaften
| XLogP | -0,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 80,9 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 10 |
| Formalladung | 0 |
| Komplexität | 283 |
| Geschmack | Sugar equivalence value relative to sucrose = 200Sweet taste ... bitter-metallic after tastethe sweetness potency relative to sucrose is about 200 |
| Dichte | 1.83 |
| Color/Form | Needles from benzene or chloroform |
| Löslichkeit | In water, 270 g/L at 20 °CSoluble in benzene, chloroform270 g/L at 20 ºC |
| Decomposition | When heated to decomposition emits toxic fumes of /sulfur oxides/. /Acesulfame potassium/ |
| Schmelzpunkt | 123.2 °CMP: 225 °C /Acesulfame potatssium/123 - 123.5 °C123-123.5° |
| Physical Description | Solid[Merck Index] |
| Stability/Shelf Life | Stable under recommended storage conditions. /Acesulfame K/ |
| Dissociation Constants | pKa = 2.0 |
| Collision Cross Section | 125.1 Ų [M-H]- [CCS Type: DTBuffer gas: N2Ionization: ESI-Dataset: TOXCASTSource Identifier: DTXSID1030606] |
| Other Experimental Properties | Density: 1.83 g/cu cm30, 40 and 90 g/100 mL water at 20, 40 and 90 °C0.4, 5, 10, 15, and 23 g/100 mL ethanol, 80%, 60%, 40% and 20% (vol) ethanol at 20 °Csolubility in g/100 mL at 20 °C: 1.0 in methanol, 0.08 in acetone, about 13 in acetic acid, about 15 in dimethyl formamide, over 30 in dimethylsulfoxide, over 60 in formic acid /Acesulfame potassium/Mol wt 201.24. Colorless, odorless powder. Decomposition point about 225 °C. Density (solid) 1.81 g/cu cmdensity (bulk) 1.1-1.3 kg/cu dm. UV max: 227 nm (epsilon 1.0762X10+4). Very soluble in water, DMF, DMSO. Soluble in alcohol, glycerin-water. Solubilty in water (g/L): about 150 (0 °C)about 210 (10 °C)about 270 (20 °C)about 360 (30 °Cabout 460 (40 °C)about 580 (50 °C)about 830 (70 °C)about 1300 (100 °C). Solubility at 20 °C (g/L): methanol about 10ethanol (anhydrous) about 1glycerol (anhydrous) about 30glycerol/water (80:20, v/v) about 82glycerol/water (50:50, v/v) about 162acetone about 0.8glacial acetic acid about 130. Solubility at 23 °C (g/L): ethanol/water (80:20 v/v) about 46ethanol/water (60:40, v/v) about 100ethanol/water (40:60, v/v) about 155ethanol/water (20:80, v/v) about 221 /Acesulfame potassium salt/White, free-flowing crystalline powder /Acesulfame potassium/At higher concentrations, there is a detectable bitter and metallic off-taste similar to saccharin. The sweetness potency of acesulfame-K (100 to 200X, depending on the matching sucrose concentration) is considered to be about half that of saccharin, which is about the same as that of aspartame. /Acesulfame potassium/ |
| pKa (Säurekonstante) | -0.28±0.40(Predicted) |
| Henry-Konstante | 1.0×103 mol/(m3Pa) at 25℃, HSDB (2015) |
| InChI | InChI=1S/C4H5NO4S/c1-3-2-4(6)5-10(7,8)9-3/h2H,1H3,(H,5,6) |
| InChIKey | YGCFIWIQZPHFLU-UHFFFAOYSA-N |
| SMILES | O1C(C)=CC(=O)NS1(=O)=O |
| CAS Datenbank | 33665-90-6(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.WarningH315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 1 of 2 reports by companies.There is 1 notification provided by 1 of 2 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Chemical: 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide |
| Gefahrenübersicht | Potassium salt: Oral LD50 (rat) = 7,430 mg/kgNot irritating to rabbit skin but irritating to rabbit eyes90-day feeding study of rats produced minor effects at highest tested dose of 10%, but no serum enzyme, gross pathological, or histological changesNo adverse effects observed in two year feeding study of dogs (doses up to 3% corresponding to 900 mg/kg/day)No evidence of reproductive, developmental, or teratogenic toxicity in ratsEmergency treatment: Non-toxic ingestion[HSDB] |
| FDA-Anforderungen | Acesulfame potassium is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient. /Acesulfame potassium/ |
| Toxic Combustion Products | Special hazards arising from the substance or mixture: Carbon oxides, nitrogen oxides (NOx), sulfur oxides, potassium oxides. /Acesulfame K/ |
| Hazard Classes and Categories | Skin Irrit. 2 (50%)Eye Irrit. 2A (50%)STOT SE 3 (50%) |
| Skin, Eye, and Respiratory Irritations | Acesulfame K was non-irritant in a primary dermal irritation test in the rabbit. /Acesulfame K/ |
| Hazardous Reactivities and Incompatibilities | Incompatible materials: Strong oxidizing agents. /Acesulfame K/ |
| Brandbekämpfungsverfahren | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. /Acesulfame K/Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary. /Acesulfame K/ |
| Lagerbedingungen | Keep container tightly closed in a dry and well-ventilated place. /Acesulfame K/ |
| Reinigungsverfahren | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing vapors, mist or gas. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal. /Acesulfame K/ |
| Entsorgungsverfahren | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Offer surplus and non-recyclable solutions to a licensed disposal companyContaminated packaging: Dispose of as unused product. /Acesulfame K/ |
| Preventive Measures | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing vapors, mist or gas. Environmental precautions: Do not let product enter drains. /Acesulfame K/Precautions for safe handling: Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. /Acesulfame K/Appropriate engineering controls: General industrial hygiene practice. /Acesulfame K/Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. /Acesulfame K/SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker. |
| Personal Protective Equipment (PPE) | Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). /Acesulfame K/Skin protection: Handle with gloves. /Acesulfame K/Body Protection: Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place. /Acesulfame K/Respiratory protection: Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). /Acesulfame K/ |
| Wechselwirkungen | The ecotoxicity of heavy metals depends much on their speciation, which is influenced by other co-existing substances having chelating capacity. In the present study, the toxic effects of Cd(2+) and Cu(2+) on a green algae Scenedesmus obliquus were examined in the presence of two artificial sweeteners (ASs), acesulfame (ACE) and sucralose (SUC) by comparing the cell specific growth rate mu and pulse-amplitude-modulated (PAM) parameters (maximal photosystem II photochemical efficiency Fv/Fm, actual photochemical efficiency Yield, and non-photochemical quenching NPQ) of the algae over a 96-hr period. Simultaneously, the bioconcentration of the metals by the algal cells in the presence of the ASs was measured. The presence of ACE enhanced the growth of S. obliquus and promoted the bioconcentration of Cd(2+) in S. obliquus, while the impacts of SUC were not significant. Meanwhile, EC50 values of Cd(2+) on the growth of S. obliquus increased from 0.42 mg/L to 0.54 mg/L and 0.48 mg/L with the addition of 1.0 mg/L ACE and SUC, respectively. As for Cu(2+), EC50 values increased from 0.13 mg/L to 0.17 mg/L and 0.15 mg/L with the addition of 1.0 mg/L ACE and SUC, respectively. In summary, the two ASs reduced the toxicity of the metals on the algae, with ACE showing greater effect than SUC. Although not as sensitive as the cell specific growth rate, PAM parameters could disclose the mechanisms involved in metal toxicity at subcellular levels. This study provides the first evidence for the possible impact of ASs on the ecotoxicity of heavy metals.Swiss Albino male mice were exposed to blends of aspartame (3.5, 35, 350 mg/kg bw) and acesulfame-K (1.5, 15 and 150mg/kg bw) by gavage. Bone marrow cells isolated from femora were analyzed for chromosome aberrations. Statistical analysis of the results show that aspartame in combination with acesulfame-K is not significantly genotoxic. /Acesulfame K//The authors/ ... investigated the ability of zinc sulfate (5, 25, 50 mM) to inhibit the sweetness of 12 chemically diverse sweeteners, which were all intensity matched to 300 mM sucrose [800 mM glucose, 475 mM fructose, 3.25 mM aspartame, 3.5 mM saccharin, 12 mM sodium cyclamate, 14 mM acesulfame-K, 1.04 M sorbitol, 0.629 mM sucralose, 0.375 mM neohesperidin dihydrochalcone (NHDC), 1.5 mM stevioside and 0.0163 mM thaumatin]. Zinc sulfate inhibited the sweetness of most compounds in a concentration dependent manner, peaking with 80% inhibition by 50 mM. Curiously, zinc sulfate never inhibited the sweetness of Na-cyclamate. This suggests that Na-cyclamate may access a sweet taste mechanism that is different from the other sweeteners, which were inhibited uniformly (except thaumatin) at every concentration of zinc sulfate. We hypothesize that this set of compounds either accesses a single receptor or multiple receptors that are inhibited equally by zinc sulfate at each concentration.The purpose of the present study was to determine the effect of repeated presentation of the same sweet stimulus on sweetness intensity ratings. The sweet stimuli tested in this study were binary and ternary blends of 14 sweeteners that varied widely in chemical structure. A trained panel evaluated the sweetness intensity over four sips of a given mixture presented at 30 s intervals. The individual components in the binary sweetener combinations were intensity-anchored with 5% sucrose, while the individual sweeteners in the ternary mixtures were intensity-anchored with 3% sucrose .... Each self-mixture was also evaluated (e.g. acesulfame-K-acesulfame-K). The main finding of this study was that mixtures consisting of two or three different sweeteners exhibited less reduction in sweetness intensity over four repeated sips than a single sweetener at an equivalent sweetness level. Furthermore, ternary combinations tended to be slightly more effective than binary combinations at lessening the effect of repeated exposure to a given sweet stimulus. These findings suggest that the decline in sweetness intensity experienced over repeated exposure to a sweet stimulus could be reduced by the blending of sweeteners.Human bitter taste is mediated by the hTAS2R family of G protein-coupled receptors. ... /This study/ employed a high-throughput screening approach to discover a novel bitter receptor antagonist (GIV3727) that inhibits activation of hTAS2R31 (formerly hTAS2R44) by saccharin and acesulfame K, two common artificial sweeteners. Pharmacological analyses revealed that GIV3727 likely act/ed/ as an orthosteric, insurmountable antagonist of hTAS2R31. Surprisingly, ... /it was/ also found that this compound could inhibit five additional hTAS2Rs, including the closely related receptor hTAS2R43. Molecular modeling and site-directed mutagenesis studies suggest/ed/ that two residues in helix 7 are important for antagonist activity in hTAS2R31 and hTAS2R43. In human sensory trials, GIV3727 significantly reduced the bitterness associated with the two sulfonamide sweeteners, indicating that hTAS2R antagonists ... /were/ active in vivo. |
| Ökotoxizitätswerte | LC50Species: Danio rerio (Zebra Fish)Concentration: about 2500 mg/L for 48 hr /Conditions of bioassay not specified in source examined/ /Acesulfame K/Concentration: 1800- 2500 mg/L for 96 hr /Conditions of bioassay not specified in source examined/ /Acesulfame K/Species: Leuciscus Idus (Golden Orfe)Concentration: >1000 mg/L /Conditions of bioassay not specified in source examined/ /Acesulfame K/ |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4(SRC), determined from a structure estimation method(2), indicates that acesulfame is expected to have very high mobility in soil(SRC). The pKa of acesulfame is 2.0(3), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Sorption tests in several soils found low adsorption of acesulfame(5). Volatilization from moist soil is not expected because the compound exists as an anion and anions do not volatilize. Acesulfame is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.0X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Acesulfame is not eliminated in wastewater treatment plants and has been shown to be very persistent in surface waters(6). Several biodegradation tests found acesulfame to be persistent to biotransformation, but biodegradation may be possible under specific conditions such as denitrifying conditions(7).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4(SRC), determined from a structure estimation method(2), indicates that acesulfame is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 2.0(3) indicates acesulfame will exist almost entirely in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(4), an estimated BCF of 3(SRC), from an estimated log Kow of -1.33(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Acesulfame is not eliminated in wastewater treatment plants and has been shown to be very persistent in surface waters(5). Several biodegradation tests found acesulfame to be persistent to biotransformation, but biodegradation may be possible under specific conditions such as denitrifying conditions(6). Acesulfame is not expected to undergo hydrolysis in the environment based on its stability in wastewater treatment and surface waters(5). Acesulfame contains an olefin bond and olefins react with photooxidants in natural waters exposed to sunlight with a half-life on the order of 25 days(7).AQUATIC FATE: Ubiquitous occurrence of the artificial sweetener acesulfame in the aquatic environment is indicated with consistent detection in untreated and treated wastewater (12-46 ug/L), in most surface waters, and detection in tapwater samples up to 2.6 ug/L in a Swiss study. The compound is not eliminated in wastewater treatment plants and proved to be very persistent in surface waters. The highest concentration in groundwater was 4.7 ug/L, in areas with greater infiltration from river water having received discharge water from wastewater treatment plants(1).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), acesulfame, which has an estimated vapor pressure of 9.0X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase acesulfame is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase acesulfame is also degraded in the atmosphere by reaction with ozone(SRC)the half-life for this reaction in air is estimated to be 1 day(SRC), calculated from its rate constant of 1.1X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase acesulfame may be removed from the air by wet and dry deposition(SRC). Acesulfame does not absorb at wavelengths >290 nm(3,4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
| Lebensmitteluntersuchungswerte | Most diet drinks dispensed from a beverage dispenser, ie, soda fountain, contain a blend of aspartame and saccharin or aspartame, acesulfame-K and saccharin, instead of 100% aspartame(1). |
| Toxizitätsübersicht | IDENTIFICATION AND USE: Acesulfame (AS) is a solid. It is used as artificial sweetener for food, also used in cosmetics. HUMAN STUDIES: A case study is reported whereby an individual with known sulfite and sulfonamide allergies develops hypersensitivity to taurine above a threshold level as well as to the non-nutritive sweetener acesulfame potassium, compounds that are not normally associated with allergic reactions. In vitro studies suggested that long-term consumption of AS might accelerate atherosclerosis and senescence via impairment of function and structure of apoA-I and HDL. ANIMAL STUDIES: Acesulfame K was non-irritant in a primary dermal irritation test in the rabbit. Acesulfame K showed no antigenic effect and only the guinea pigs sensitized with BSA showed anaphylactic reactions. Acesulfame K was not carcinogenic in mice or rats. A multigeneration study in rats was carried out, in which males and females received Acesulfame K at dietary levels of 0, 0.3, 1.0 and 3.0% for three successive generations, each comprising two consecutive litters. Growth rate was slightly decreased in the top dose group of the F0 and F1 generations, and the mid-dose group of the F0 generation. In the teratogenicity studies, no adverse effects were seen in appearance, food consumption, autopsy of the dams, organ weights, or litter datano visceral or skeletal abnormalities attributable to the treatment were observed. Acesulfame K was negative in the genotoxicity studies in vivo and in vitro, including Ames tests in S. typhimurium TA98, TA100, TA15325, TA1537, TA1538 at 0-100 mg/plate, 4-5000 ug/plate and in E.Coli WP2uvrA at 4-5000 ug/plate. ECOTOXICITY STUDIES: AS is listed as an emerging contaminant due to its environmental persistence and wide occurrence in the environment. An increased toxicity of AS after UV irradiance was observed in the liver of Carassius auratus exposed to AS and its irradiation products. Embryotoxicity tests showed that AS transformation products at t |
| Average Daily Intake | FDA and JECFA (Joint Expert Committee on Food Additives) have established an acceptable daily intake (ADI) of 15 mg per kg of body weight for acesulfame (potassium salt). This is approximately equivalent to 6 cans of diet soft drink. The European Food Safety Authority has set the ADI at 9 mg per kg of body weight(1). |
| Ökotoxizitätsauszüge | /AQUATIC SPECIES/ Acesulfame (ACE) is listed as an emerging contaminant due to its environmental persistence and wide occurrence in the environment. ACE can be degraded partially in the regular UV disinfection process but the eco-toxicity of its irradiation products remains unclear. This study focused on the possible oxidative status change in the liver of Carassius auratus exposed to ACE and its irradiation products. The UV degradation of ACE follows pseudo-first-order kinetics, and eight irradiation products were identified. Fish were exposed 7 days to 0.1 and 10 mg/L ACE (ACE group) and ACE after UV irradiance (ACE-UV group). The oxidative stress in fish liver exposed to ACE group had no distinct change. However, in the ACE-UV group, the quantity of OH was induced by 17.96-55% and the MDA content increased by 16.28-68.28% compared to control. Time-effect exposure in the ACE-UV group showed that in the first 3 days the quantity of OH reached its peak, causing severe inhibition of SOD and continuous inducement of GPx. GSH helped scavenge OH and decreased below control after 3 days. An increased toxicity of ACE after UV irradiance was observed and its transfer after into aquatic environment needs to be recognized as an environmental risk. |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for acesulfame potassium is available. /Acesulfame potassium/[Available from, as of November 3, 2017: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status] |
| Effluent Concentrations | Acesulfame was detected in both influent and effluents from wastewater treatment plants in Tianjin China in 2011(1). In 2010, effluents from 90 European wastewater treatment plants (WWTPs) were analyzed for 156 polar organic chemical contaminants, and acesulfame was detected at a frequency of 93% with average, median and maximum concentrations of 76 ug/L, 14.3 ug/L, and 2.5 mg/L respectively(2).[Table#4665] |
| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc of acesulfame can be estimated to be 4(SRC). According to a classification scheme(2), this estimated Koc value suggests that acesulfame is expected to have very high mobility in soil. The pKa of acesulfame is 2.0(3), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Batch sorption tests in several soils found low adsorption of acesulfame with estimated Kd values of <0.1 L/kg(5). |
| Atmospheric Concentrations | URBAN/SUBURBAN: Ambient air monitoring conducted in Tianjin China in 2011 detected acesulfame in both the gas and particulate phases at concentrations of 1.60-5.80 and 2.50-18.0 pg/cu m respectively(1). Acesulfame was also detected in precipitation samples at levels of approximately 20-150 ng/L(1). |
| Human Toxicity Excerpts | /CASE REPORTS/ A case study is reported whereby an individual with known sulfite and sulfonamide allergies develops hypersensitivity to taurine above a threshold level as well as to the non-nutritive sweetener acesulfame potassium, compounds that are not normally associated with allergic reactions. Sulfites, sulfonamides, taurine and acesulfame potassium all contain a SO3 moiety. Challenge tests provide evidence for the hypersensitivities to taurine and acesulfame potassium. The subject is also allergic to thiuram mix and thimerosal, sulfur containing compounds, as well as to various food products. This may be the first case where hypersensitivities to taurine and acesulfame potassium have been documented and reported. Several mechanistic explanations are provided for the untoward reactions to taurine and acesulfame potassium. /Acesulfame potassium//ALTERNATIVE and IN VITRO TESTS/ Long-term consumption of artificial sweeteners (AS) has been the recent focus of safety concerns. However, the potential risk of the AS in cardiovascular disease and lipoprotein metabolism has not been investigated sufficiently. We compared the influence of AS (aspartame, acesulfame K, and saccharin) and fructose in terms of functional and structural correlations of apolipoprotein (apo) A-I and high-density lipoproteins (HDL), which have atheroprotective effects. Long-term treatment of apoA-I with the sweetener at physiological concentration (3 mM for 168 hr) resulted in loss of antioxidant and phospholipid binding activities with modification of secondary structure. The AS treated apoA-I exhibited proteolytic cleavage to produce 26 kDa-fragment. They showed pro-atherogenic properties in acetylated LDL phagocytosis of macrophages. Each sweetener alone or sweetener-treated apoA-I caused accelerated senescence in human dermal fibroblasts. These results suggest that long-term consumption of AS might accelerate atherosclerosis and senescence via impairment of function and structure of apoA-I and HDL. /Acesulfame K//ALTERNATIVE and IN VITRO TESTS/ Food constituents may cause a phenomenon of food-drug interactions. In the current study, we examined the effects of artificial sweeteners (aspartame, acesulfame, cyclamate, saccharin) on the aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)-dependent expression of CYP1A1 in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cell lines. Sweeteners were tested in concentrations up to those occurring in non-alcoholic beverages. Basal and ligand-inducible AhR- and GR-dependent reporter gene activation in stably transfected HepG2 and HeLa cells, respectively, were not affected by either of the sweeteners tested after 24 hr of incubation. The expression of CYP1A1 mRNA and protein in primary cultures of human hepatocytes and in LS174T and HepG2 cells was not induced by any of the tested sweeteners. Overall, aspartame, acesulfame, saccharin and cyclamate had no effects on CYP1A1 expression and transcriptional activities of AhR and GR. These data imply the safety of artificial sweeteners in terms of interference with AhR, GR and CYP1A1./OTHER TOXICITY INFORMATION/ Sweet taste receptors may enhance glucose absorption. This study aimed to explore the cell biology of sweet taste receptors on glucose uptake. /The hypothesis was that/ artificial sweeteners increase glucose uptake via activating sweet taste receptors in the enterocyte to translocate GLUT2 to the apical membrane through the PLC betaII pathway. Caco-2, RIE-1, and IEC-6 cells, starved from glucose for 1 hr were pre-incubated with 10 mM acesulfame potassium (AceK). Glucose uptake was measured by incubating cells for 1 to 10 min with 0.5-50 mM glucose with or without U-73122, chelerythrine, and cytochalasin B. In Caco-2 and RIE-1 cells, 10 mM AceK increased glucose uptake by 20-30% at glucose >25 mM, but not in lesser glucose concentrations (<10 mM), nor at 1 min or 10 min incubations. U-73122 (PLC betaII inhibitor) inhibited uptake at glucose >25 mM and for 5 min incubationchelerythrine and cytochalasin B had similar effects. No effect occurred in IEC-6 cells. Activation of sweet taste receptors had no effect on glucose uptake in low (<25 mM) glucose concentrations but increased uptake at greater concentrations (>25 mM). Role of artificial sweeteners on glucose uptake appears to act in part by effects on the enterocyte itself. /Acesulfame potassium/For more Human Toxicity Excerpts (Complete) data for Acesulfame (7 total), please visit the HSDB record page. |
| Wassergefährdungsklasse (WGK) | 1 |
| RTECS-Nr. | RP4489165 |
| Gefahrstoffdaten | 33665-90-6(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
Acesulfame-K is a non-nutritive sweetener also termed acesulfame potassium. it is a white, crystalline product that is 200 times sweeter than sucrose. it is not metabolized in the body. it has some metallic off-tastes. it is readily soluble and heat and acid stable. it provides a synergistic sweetening effect combined with other sweeteners. it is used in beverages, desserts, confectionery, and bakery products.