HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Promegestone
R5020 · RU-5020 · PROMEGESTONE · PROMEGESTONE USP/EP/BP · Nicotinamide Impurity 137 · 17α-Methyl-17β-propionylestra-4,9-dien-3-one · Estra-4,9-dien-3-one, 17-methyl-17-(1-oxopropyl)-, (17β)-
Identifikatoren & physikalische Daten
| CAS No. | 34184-77-5 |
|---|---|
| Summenformel | C22H30O2 |
| Durchschnittliche Molmasse | 326,5 g/mol |
| Monoisotopische Masse | 326,2245802 g/mol |
| SMILES | CCC(=O)[C@@]1(C)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3CC[C@@]21C |
| InChIKey | QFFCYTLOTYIJMR-XMGTWHOFSA-N |
| PubChem CID | 36709 |
| ChEMBL | CHEMBL196003 |
| ChEBI | CHEBI:73390 |
| EC No. | 682-405-8 |
| DTXSID | DTXSID4036510 |
Chemische & physikalische Eigenschaften
| XLogP | 3,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 34,1 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 24 |
| Formalladung | 0 |
| Komplexität | 667 |
| LogP (Verteilungskoeffizient) | 4.05 |
| Schmelzpunkt | 152° |
| Siedepunkt | 486.8±45.0 °C(Predicted) |
| Dichte | 1.09±0.1 g/cm3(Predicted) |
| Aggregatzustand | Solid |
| Farbe | White to off-white |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH340 (97.4%): May cause genetic defects [Danger Germ cell mutagenicity]P203, P280, P318, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Muta. 1B (97.4%) |
| Alarmwort | Achtung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H340 |
Anwendungen & Verwendung
Beschreibung
Promegestone is a potent progesterone-like agent devoid of androgenic properties, and thus masculinizing side effects. It is useful in the treatment of various gynecological conditions due to luteal insufficiency, such as premenopausal disorders, dysmenorrhea, and premenstrual syndrome.
Verwenden
As radioligand for the progestin receptor.