Phenelzin

nadil · Nardil · W-1544 · w1544-a · W 1544-A · Fenelzyne · Fenelzyna · Stinerval

Identifikatoren & physikalische Daten

CAS No.	51-71-8
Summenformel	C8H12N2
Durchschnittliche Molmasse	136,19 g/mol
Monoisotopische Masse	136,10004838 g/mol
SMILES	NNCCc1ccccc1
InChIKey	RMUCZJUITONUFY-UHFFFAOYSA-N
PubChem CID	3675
ChEMBL	CHEMBL1089
ChEBI	CHEBI:8060
EC No.	200-117-9
DTXSID	DTXSID2041094
Lokaler Name	Phenelzin

Chemische & physikalische Eigenschaften

XLogP	1,2
Polarare Oberfläche (TPSA)	38,1
H-Brücken-Donoren	2
H-Brücken-Akzeptoren	2
Frei drehbare Bindungen	3
Schwere Atome	10
Formalladung	0
Komplexität	77,3
Arzneimittel	Pharmaceuticals -> Listed in ZINC15
LogP (Verteilungskoeffizient)	1.1
Color/Form	Liquid
Löslichkeit	1.11e+01 g/L
Human Drugs	Antidepressants -> Monoamine oxidase inhibitors (MAOI)Breast FeedingLactationAntidepressive AgentsMonoamine Oxidase InhibitorsPharmaceuticals
Siedepunkt	BP: 74 °C at 0.1 mm Hgbp0.1 74°
Decomposition	When heated to decomposition material emits toxic fumes of /sulfur oxides and nitrogen oxides/.
Schmelzpunkt	157-161ºCCrystalsmp: 174 °C /Phenelzine hydrochloride/< 25 °C25°C
Brechungsindex	Index of refraction: 1.5494 at 20 °C/DnD20 1.5494
Physical Description	Solid
Dissociation Constants	6.5-8
Collision Cross Section	113.9 Å² [M-N2H3]+ [CCS Type: DTBuffer gas: N2Ionization: ESI+Dataset: Antidepressants]132.72 Å² [M+K]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
Dichte	1.0348 (rough estimate)
pKa (Säurekonstante)	8.01±0.70(Predicted)
Henry-Konstante	2.9×103 mol/(m3Pa) at 25℃, HSDB (2015)
CAS Datenbank	51-71-8(CAS DataBase Reference)
NIST chemische Informationen	Hydrazine, (2-phenylethyl)-(51-71-8)
EPA chemische Informationen	Phenelzine (51-71-8)

Sicherheit & Vorschriften

GHS-Einstufung	DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Regulatorische Informationen	Phenelzine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Weitere Sicherheitsinformationen	IMAP assessments - Hydrazine, (2-phenylethyl)-: Human health tier I assessment
Brandpotenzial	This material is assumed to be combustible.
FDA-Anforderungen	The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including phenelzine sulfate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Toxic Combustion Products	Emits toxic fumes under fire conditions.
Hazard Classes and Categories	Acute Tox. 3 (100%)
Brandbekämpfungsverfahren	Water spray, dry chemical, carbon dioxide or foam as appropriate for surrounding fire and materials.As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.
Lagerbedingungen	Commercially available phenelzine sulfate tablets should be stored in tight containers at a temperature between 15-30 °Cthe tablets should be protected from excessive exposure to heat and light.Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. Protect from heat.
Reinigungsverfahren	Wear approved respiratory protection, chemically compatible gloves and protective clothing. Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site.

Anwendungen & Verwendung

Beschreibung

Monoamine oxidase inhibitors (MAOIs) were the first antidepressant drugs introduced during the 1950s. Associated with many side effects and, in particular, drug–drug and drug–food interactions, their use declined with the subsequent introduction of the tricyclic antidepressants and specific serotonin reuptake inhibitors as first-line treatments for depression.

Verwenden

Phenelzine is a MAO inhibitor which is used for treating patients with depressive characteristics such as “atypical,” “nonendogenous,” or “neurotic” conditions in which a combination of anxiety, depression, or phobia are observed. Phenelzine is not a drug of first choice, and it is used in depressions that do not respond to other medicinal drugs.