HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Indapamid
INDAPAMID · indaflex · ndapamide · Idapamide · Indapamide CRS · N-(4-CHLORO-3-SULFAMOYLBENZAMIDO)-2-METHYLINDOLINE · 4-chloro-N-[(2S)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfaMoylbenzaMide · s1520
Identifikatoren & physikalische Daten
| CAS No. | 26807-65-8 |
|---|---|
| Summenformel | C16H16ClN3O3S |
| Durchschnittliche Molmasse | 365,8 g/mol |
| Monoisotopische Masse | 365,0600902 g/mol |
| SMILES | CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1 |
| InChIKey | NDDAHWYSQHTHNT-UHFFFAOYSA-N |
| PubChem CID | 3702 |
| ChEMBL | CHEMBL406 |
| ChEBI | CHEBI:5893 |
| EC No. | 248-012-7 |
| DTXSID | DTXSID7044633 |
| Lokaler Name | Indapamid |
Chemische & physikalische Eigenschaften
| XLogP | 2,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 101 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 24 |
| Formalladung | 0 |
| Komplexität | 580 |
| Arzneimittel | PharmaceuticalsPharmaceuticals -> Diuretics |
| LogP (Verteilungskoeffizient) | 2.21.83 |
| Löslichkeit | 3.42e-02 g/L>54.9 [ug/mL] (The mean of the results at pH 7.4)Practically insoluble in water, soluble in ethanol (96 per cent).Soluble in ethanol. Insoluble in water |
| Human Drugs | Breast FeedingLactationMilk, HumanAntihypertensive AgentsThiazide DiureticsFDA approved drugs -> Active ingredientPharmaceuticalsAntihypertensive medicines |
| Schmelzpunkt | 160-162161 °C160-162°C |
| Physical Description | Solid |
| Dissociation Constants | 8.8 |
| Collision Cross Section | 195.9 Ų [M+Na]+ [CCS Type: DTBuffer gas: N2Ionization: ESI+Dataset: TOXCASTSource Identifier: DTXSID7044633]184.6 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]191.35 Ų [M+Na]+ [CCS Type: TW185.6 Ų [M+H]+ [CCS Type: TWMethod: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Siedepunkt | 110.4°C (rough estimate) |
| Dichte | 1.2895 (rough estimate) |
| Brechungsindex | 1.6100 (estimate) |
| Lagerbedingungen | -20°C Freezer |
| pKa (Säurekonstante) | pKa (25°) 8.8 ± 0.2 |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| Merck | 14,4935 |
| BCS Class | 1 |
| InChIKey | NDDAHWYSQHTHNT-UHFFFAOYSA-N |
| CAS Datenbank | 26807-65-8(CAS DataBase Reference) |
| EPA chemische Informationen | Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)- (26807-65-8) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 1.5% (1 of 68) of reports.WarningH361 (86.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]P203, P280, P318, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 68 reports by companies from 14 notifications to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | Indapamide: Non hazardous |
| Hazard Classes and Categories | Repr. 2 (86.8%) |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)IndapamideAmbiguous-DILI-concern5Adverse reactionsDOI:10.1016/j.drudis.2016.02.015 |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
| Wassergefährdungsklasse (WGK) | 2 |
| Zollcode | 2935904000 |
| RTECS-Nr. | CV2451200 |
| Toxizität | LD50 in rats, mice, guinea pigs (mg/kg): 393-421, 410-564, 347-416 i.p.394-440, 577-635, 272-358 i.v.>3000 all species orally (Kyncl) |
Anwendungen & Verwendung
Beschreibung
Indapamide is a derivative of benzolsulfonamide and its mechanism of action is analogous to that of thiazides. It is intended for lowering arterial blood pressure and as an adjuvant drug for treating edema caused by cardiac insufficiency. Indapamide can be detected in urine. This product is intended for research and forensic applications.