HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
K-252C
6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one · K-252C · Staurosporonine · Staurosporinone · STAUROSPORINE AGLYCONE · K-252c(Staurosporinone) · Staurosporinone, K-252c · K252c, Ready Made Solution
Identifikatoren & physikalische Daten
| CAS No. | 85753-43-1 |
|---|---|
| Summenformel | C20H13N3O |
| Durchschnittliche Molmasse | 311,3 g/mol |
| Monoisotopische Masse | 311,10586204 g/mol |
| SMILES | O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21 |
| InChIKey | MEXUTNIFSHFQRG-UHFFFAOYSA-N |
| PubChem CID | 3815 |
| ChEMBL | CHEMBL16958 |
| ChEBI | CHEBI:204201 |
| EC No. | 632-917-2 |
| DTXSID | DTXSID801017989 |
Chemische & physikalische Eigenschaften
| XLogP | 3,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 60,7 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 24 |
| Formalladung | 0 |
| Komplexität | 551 |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Schmelzpunkt | >200°C (dec.) |
| Lagerbedingungen | −20°C |
| Löslichkeit | DMSO: 10 mg/mL, solubleSoluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water. |
| Aggregatzustand | solid |
| Farbe | Pale Brown to Light Brown |
| InChI | InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24) |
| InChIKey | MEXUTNIFSHFQRG-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C2=C1C1NC3=C(C=1C1CNC(=O)C=12)C=CC=C3 |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| UN-Transportnummer | NA 1993 / PGIII |
| Zollcode | 29333990 |
| Sicherheitshinweise (S) | 22-24/25 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Acute Tox. 4 OralEye Irrit. 2 |
Anwendungen & Verwendung
Verwenden
Inhibits protein kinase C