Guanadrel
C07035 · Guanadrel · Guanadrel USP/EP/BP · N-(1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine · 1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine · 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine · Guanidine, N-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)- · 2-((1,4-dioxaspiro[4.5]decan-2-yl)methyl)guanidine
Identifikatoren & physikalische Daten
| CAS No. | 40580-59-4 |
|---|---|
| Summenformel | C10H19N3O2 |
| Durchschnittliche Molmasse | 213,28 g/mol |
| SMILES | NC(N)=NCC1COC2(CCCCC2)O1 |
| InChIKey | HPBNRIOWIXYZFK-UHFFFAOYSA-N |
| PubChem CID | 38521 |
| ChEMBL | CHEMBL1037 |
| ChEBI | CHEBI:5555 |
Chemische & physikalische Eigenschaften
| Siedepunkt | 341.5±40.0 °C(Predicted) |
|---|---|
| Dichte | 1.39±0.1 g/cm3(Predicted) |
| Lagerbedingungen | -20°C |
| Löslichkeit | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| Aggregatzustand | A solid |
| pKa (Säurekonstante) | 12.59±0.70(Predicted) |
| Farbe | Colorless to light yellow |
Anwendungen & Verwendung
Beschreibung
Guanadrel is an adrenergic neuron blocker used for essential hypertension. Its mechanism of action and side effects are similar to those of guanethidine.
Verwenden
Guanadrel is an adrenergic neuron blocker used for essential hypertension. The mechanism of action and side effects are similar to guanethidine. It is used for treating hypertension in patients who do not respond to thiazide diuretics. It can be used as an adjuvant drug in thiazide treatment for reaching an optimal level of blood pressure.