Beta-Lapachone
Grundinformationen
- CAS
4707-32-8- Standard-SMILES
CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O- InChIKey
QZPQTZZNNJUOLS-UHFFFAOYSA-N- Summenformel
- C15H14O3
- Durchschnittliche Molmasse
- 242,27 g/mol
- Monoisotopische Masse
- 242,09429431
Überblick
Beta-lapachone is a benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities. It has a role as an antineoplastic agent, an anti-inflammatory agent and a plant metabolite. It is a member of orthoquinones and a benzochromenone.
Namen und Bezeichner
- Bevorzugter Name
- Beta-Lapachone
- IUPAC
- 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione
- Englischer Name
- BETA-LAPACHONE
- Summenformel
- C15H14O3
- Molmasse
- 242.27
Namen und Synonyme
beta-Lapachone4707-32-8lapachoneLapachone, beta-3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-B]pyran-5,6-dioneARQ 501Beta-lap-wjARQ-5013,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione6N4FA2QQ6ANSC-263262,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione
Weitere Namen anzeigen
β-Lapachoneb-LapachoneCO-501SL 11001NSC 26326NSC 629749--Lapachoneβ-Lapachone (90%)
Beta lapachoneNSC-6297492H-Naphtho[1,2-b]pyran-5,6-dione, 3,4-dihydro-2,2-dimethyl-NSC26326NSC6297492H-Naphtho(1,2-b)pyran-5,6-dione, 3,4-dihydro-2,2-dimethyl-ARQ501CHEBI:10429
Datenbank-Bezeichner
- CAS
4707-32-8- PubChem CID
- 3885
- DTXSID
DTXSID90197019- ChEMBL
CHEMBL15192
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,2
- Polarare Oberfläche (TPSA)
- 43,4 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 18
- Formalladung
- 0
- Komplexität
- 445
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Listed in ZINC15
Physikochemische Eigenschaften
- Schmelzpunkt
- 110 °C · >110°C (dec.)
- Siedepunkt
- 381.4 · 381.4±42.0 °C(Predicted)
- Dichte
- 1.25 · 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
- Aggregatzustand
- Orange to brown solid.
- Farbe
- Orange
- Biologische Quelle
- synthetic (organic)
- Stabilität
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code
- Kosmetik-Inhaltsstoffe Funktionen
- ANTIMICROBIALSKIN CONDITIONING - MISCELLANEOUS
- InChI
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2932990090
- RTECS-Nr.
- QL6127400
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.
Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
Anwendungen
Verwendenβ-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. Induces apoptosis in HL-60 and human prostate cancer cells.
Vor- und nachgelagerte Produkte
Nachgelagerte Produkte
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南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
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武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
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