Linopirdine
Grundinformationen
- CAS
105431-72-9- Standard-SMILES
O=C1N(c2ccccc2)c2ccccc2C1(Cc1ccncc1)Cc1ccncc1- InChIKey
YEJCDKJIEMIWRQ-UHFFFAOYSA-N- Summenformel
- C26H21N3O
- Durchschnittliche Molmasse
- 391,5 g/mol
- Monoisotopische Masse
- 391,1684623
Überblick
Linopirdine is a member of indoles.
Namen und Bezeichner
- Bevorzugter Name
- Linopirdine
- IUPAC
- 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
- Englischer Name
- 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
- Summenformel
- C26H21N3O
- Molmasse
- 391.46
Namen und Synonyme
Linopirdine105431-72-9Dup 9961-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-oneDuP-996LinopirdinaI5TB3NZ94T2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-1-phenyl-3,3-bis(4-pyridylmethyl)indolin-2-one3,3-bis(4-pyridylmethyl)-1-phenylindolin-2-onelinopirdinum3,3-dipyridylmethyl-1-phenyl-2-indolinone
Weitere Namen anzeigen
linopiridineLinopirdine2HClLINOPIRDINE (DUP996)Linopirdine, 10 mM in DMSOLINOPIRDINE DIHYDROCHLORIDE1-Phenyl-3,3-bis(4-pyridinylmethyl)-2,3-dihydro-1H-indole-2-one1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride
RefChem:924805N06BX091,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-oneDTXSID6045163MFCD008672161-Phenyl-3,3-bis(4-pyridinylmethyl)-2-indolinoneNCGC00015590-03
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 4,1
- Polarare Oberfläche (TPSA)
- 46,1 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 30
- Formalladung
- 0
- Komplexität
- 555
Physikochemische Eigenschaften
- Schmelzpunkt
- 186 · 186-186.5 °C
- Siedepunkt
- 655.9 · 655.9±50.0 °C(Predicted)
- Dichte
- 1 · 1+-.0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- Löslichkeit
- 10 mg/mL · DMSO: >10mg/mL
- pka
- 6.01 · 6.01±0.10(Predicted)
- Aggregatzustand
- A crystalline solid
- Farbe
- white to off-white
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
Chemie und Industrie
Pharmakologische Informationen
ATC Code
N - Nervous system
QN - Nervous system
MeSH Pharmacological Classification
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
Anwendungen
BeschreibungLinopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 μM. Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release. Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory. Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 μM in HEK293 cells voltage clamped at -60 mV).
VerwendenAlzheimer’s disease treatment (cognition enhancer).
Anbieter39 Anbieter
成都超九八生物科技有限公司
Zugehörige Reaktionen
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