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Lomefloxacin
Lomefloxacine · LFLX · dm-10 · Clfimono · SC 47111A · Lomel9act · LOMEFLOXACIN · LEMOFLOXACIN
Identifikatoren & physikalische Daten
| CAS No. | 98079-51-7 |
|---|---|
| Summenformel | C17H19F2N3O3 |
| Durchschnittliche Molmasse | 351,35 g/mol |
| Monoisotopische Masse | 351,13944791 g/mol |
| SMILES | CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c21 |
| InChIKey | ZEKZLJVOYLTDKK-UHFFFAOYSA-N |
| PubChem CID | 3948 |
| ChEMBL | CHEMBL561 |
| ChEBI | CHEBI:116278 |
| EC No. | 619-317-6 |
| DTXSID | DTXSID4040680 |
Chemische & physikalische Eigenschaften
| XLogP | -0,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 72,9 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 8 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 25 |
| Formalladung | 0 |
| Komplexität | 585 |
| Arzneimittel | Pharmaceuticals -> AntibioticsPharmaceuticals -> Anti infectives for systemic use -> Antibacterials for systemic use |
| LogP (Verteilungskoeffizient) | 2.8 |
| Löslichkeit | 1.06e-01 g/LDMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| Human Drugs | Breast FeedingLactationMilk, HumanAnti-Infective AgentsAntibacterial AgentsQuinolonesFluoroquinolones |
| Schmelzpunkt | 239-240.5 °C239 - 240.5 °C239-240 C |
| Physical Description | Solid |
| Dissociation Constants | 5.742 |
| Collision Cross Section | 191.3 Ų [M+H]+ [CCS Type: TWMethod: calibrated with Waters Major Mix]191.04 Ų [M+K]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Siedepunkt | 542.7±50.0 °C(Predicted) |
| Dichte | 1.342±0.06 g/cm3(Predicted) |
| Lagerbedingungen | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | -0.25±0.20(Predicted) |
| Farbe | Pale Yellow to Light Yellow |
| CAS Datenbank | 98079-51-7(CAS DataBase Reference) |
| EPA chemische Informationen | 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- (98079-51-7) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | Status: Active Update: 17-03-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/19305 |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)lomefloxacinDILI NegativeOralDOI:10.1016/j.drudis.2019.09.022 |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 29419000 |
| RTECS-Nr. | VB1997500 |
| R-Sätze (R) | 22-36/37/38 |
| Toxizität | LD50 in mice (mg/kg): 245.6 i.v.>4000 orally (Itoh) |
| Gefahrensymbole | Xn,Xi |
| Sicherheitshinweise (S) | 26-36 |
Anwendungen & Verwendung
Beschreibung
Lomefloxacin is a once-daily, third-generation quinolone antibiotic useful in the treatment of bacterial infections. The new fluorinated quinolone does not interfere with the metabolism of theophylline; it is efficacious against pathogens resistant to cephalosporins, penicillins and aminoglycosides.
Verwenden
Anti bacterial.