Acetimidoquinone
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Grundinformationen
- CAS
50700-49-7- Standard-SMILES
CC(=O)N=C1C=CC(=O)C=C1- InChIKey
URNSECGXFRDEDC-UHFFFAOYSA-N- Summenformel
- C8H7NO2
- Durchschnittliche Molmasse
- 149,149 g/mol
- Monoisotopische Masse
- 149,04767846
Namen und Bezeichner
- Bevorzugter Name
- Acetimidoquinone
- IUPAC
- N-(4-Oxocyclohexa-2,5-dien-1-ylidene)acetamide
- Englischer Name
- N-ACETYL-4-BENZOQUINONE IMINE
- Summenformel
- C8H7NO2
- Molmasse
- 149.15
Namen und Synonyme
napqiN-ACETYL-P-BENZOQUINONE IMINEN-AcetylimidoquinoneN-Acetyl-p-benzoquinonimineChebi:29132synthesis-28acetimidoquinonen-acetyl-p-quinonimineN-ACETYL-PARA-QUINONEIMINEN-ACETYLBENZOQUINONE-IMINE
Datenbank-Bezeichner
- CAS
50700-49-7- PubChem CID
- 39763
- DTXSID
DTXSID20198756- ChEMBL
CHEMBL33232- ChEBI
CHEBI:29132- UNII
- G6S9BN13TI
- EC Number
- 640-545-7
- Nikkaji
- J3.514I
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 74 · 74-75
- Siedepunkt
- 255.6 · 255.6±43.0 °C(Predicted)
- Dichte
- 1.13 · 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -70 °C · -70°C
- Löslichkeit
- Chloroform (Slightly, Sonicated), DMSO (Slightly)
- Aggregatzustand
- Solid
- pka
- -3.37 · -3.37±0.20(Predicted)
- Farbe
- Pale Yellow to Very Dark Red
- Stabilität
- Temperature, Moisture, Light, and Oxygen Sensitive
- InChI
- 1S/C8H7NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5H,1H3
- InChIKey
- URNSECGXFRDEDC-UHFFFAOYSA-N
- SMILES
- CC(=O)\N=C1\C=CC(=O)C=C1
- CAS Datenbank
- 50700 · 50700-49-7
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2902110000
- RTECS-Nr.
- AC6960000
- Toxizität
- LD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson)
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungN-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
VerwendenN-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
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Anbieter51 Anbieter
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]
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