Mafenid

Mafenide

HCID 3998CAS 138-39-6
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Grundinformationen

Standard-SMILES
NCc1ccc(S(N)(=O)=O)cc1
InChIKey
TYMRLRRVMHJFTF-UHFFFAOYSA-N
Summenformel
C7H10N2O2S
Durchschnittliche Molmasse
186,23 g/mol
Monoisotopische Masse
186,04629856

Überblick

Mafenide is an aromatic amine.

Namen und Bezeichner

Bevorzugter Name
Mafenide
IUPAC
4-(aminomethyl)benzenesulfonamide
Lokaler Name
Mafenid
Englischer Name
4-(Aminomethyl)benzenesulfonamide
Summenformel
C7H10N2O2S
Molmasse
186.23

Namen und Synonyme

mafenide138-39-64-(Aminomethyl)benzenesulfonamideSulfamylonAmbamideBenzenesulfonamide, 4-(aminomethyl)-HomosulfanilamideMaphenidSepticidMafenidaBensulfamideMafenidum
Weitere Namen anzeigen
MaphenideHomosulfamineMesudinHomosulHomonalEmileneMalfaminMesudrin
p-(Aminomethyl)benzenesulfonamideNSC-34632alpha-Amino-p-toluenesulfonamideD06BA0358447S8P4LDTXSID6047860Sulfabenzamine4 Homosulfanilamide

Datenbank-Bezeichner

CAS
138-39-6
PubChem CID
3998
DTXSID
DTXSID6047860
ChEMBL
CHEMBL419
ChEBI
CHEBI:6633
UNII
58447S8P4L
EC Number
205-326-9
Nikkaji
J812E

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-0,7
Polarare Oberfläche (TPSA)
94,6 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
2
Schwere Atome
12

Experimentelle und physikochemische Eigenschaften

Drugs · 2 Einträge

Pharmaceuticals -> Antibiotics

Pharmaceuticals -> Listed in ZINC15

Collision Cross Section128.04 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physikochemische Eigenschaften

Schmelzpunkt
177 · 177-178℃ (decomposition)
Siedepunkt
382 · 382.0±44.0 °C(Predicted)
Dichte
1.345 · 1.345±0.06 g/cm3(Predicted)
storage temp.
2 · 2-8°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid

Sicherheit und Regulatorisches

Sicherheitsdaten

hazard_class
IRRITANT

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

D - Dermatologicals

QD - Dermatologicals

Mechanism of ActionThe precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.
Metabolism/MetabolitesMetabolized to a carbonic anhydrase inhibitor.
FDA Pharmacological Classification · 5 Einträge

58447S8P4L

MAFENIDE

Established Pharmacologic Class [EPC] - Methylated Sulfonamide Antibacterial

Methylated Sulfonamides [EXT]

Mafenide is a Methylated Sulfonamide Antibacterial.

MeSH Pharmacological Classification · 3 Einträge

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.

A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.

Substances that inhibit the growth or reproduction of BACTERIA.

Absorption, Distribution and Excretion · 2 Einträge

Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration.

Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine.

Anwendungen

Verwendenantibacterial

Vor- und nachgelagerte Produkte

Anbieter46 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
湖北金梭生物科技有限公司00123456789 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
Aladdin Scientific[email protected]

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