Mafenid
Mafenide
Grundinformationen
- CAS
138-39-6- Standard-SMILES
NCc1ccc(S(N)(=O)=O)cc1- InChIKey
TYMRLRRVMHJFTF-UHFFFAOYSA-N- Summenformel
- C7H10N2O2S
- Durchschnittliche Molmasse
- 186,23 g/mol
- Monoisotopische Masse
- 186,04629856
Überblick
Mafenide is an aromatic amine.
Namen und Bezeichner
- Bevorzugter Name
- Mafenide
- IUPAC
- 4-(aminomethyl)benzenesulfonamide
- Lokaler Name
- Mafenid
- Englischer Name
- 4-(Aminomethyl)benzenesulfonamide
- Summenformel
- C7H10N2O2S
- Molmasse
- 186.23
Namen und Synonyme
mafenide138-39-64-(Aminomethyl)benzenesulfonamideSulfamylonAmbamideBenzenesulfonamide, 4-(aminomethyl)-HomosulfanilamideMaphenidSepticidMafenidaBensulfamideMafenidum
Weitere Namen anzeigen
MaphenideHomosulfamineMesudinHomosulHomonalEmileneMalfaminMesudrin
p-(Aminomethyl)benzenesulfonamideNSC-34632alpha-Amino-p-toluenesulfonamideD06BA0358447S8P4LDTXSID6047860Sulfabenzamine4 Homosulfanilamide
Datenbank-Bezeichner
- CAS
138-39-6- PubChem CID
- 3998
- DTXSID
DTXSID6047860- ChEMBL
CHEMBL419- ChEBI
CHEBI:6633- UNII
- 58447S8P4L
- EC Number
- 205-326-9
- Nikkaji
- J812E
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -0,7
- Polarare Oberfläche (TPSA)
- 94,6 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 12
- Formalladung
- 0
- Komplexität
- 224
Experimentelle und physikochemische Eigenschaften
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Listed in ZINC15
Collision Cross Section128.04 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 177 · 177-178℃ (decomposition)
- Siedepunkt
- 382 · 382.0±44.0 °C(Predicted)
- Dichte
- 1.345 · 1.345±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 10.16 · 10.16±0.10(Predicted)
- Farbe
- Light Beige to Beige
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- hazard_class
- IRRITANT
Chemie und Industrie
Pharmakologische Informationen
ATC Code
D - Dermatologicals
QD - Dermatologicals
Mechanism of ActionThe precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.
Metabolism/MetabolitesMetabolized to a carbonic anhydrase inhibitor.
FDA Pharmacological Classification
58447S8P4L
MAFENIDE
Established Pharmacologic Class [EPC] - Methylated Sulfonamide Antibacterial
Methylated Sulfonamides [EXT]
Mafenide is a Methylated Sulfonamide Antibacterial.
MeSH Pharmacological Classification
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.
Substances that inhibit the growth or reproduction of BACTERIA.
Absorption, Distribution and Excretion
Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration.
Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine.
Anwendungen
Verwendenantibacterial
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Zugehörige Reaktionen
34
Notizen zur Verbindung
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