Sulfacetamidnatrium

Sodium Sulfacetamide

HCID 4022878CAS 127-56-0

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Grundinformationen

Standard-SMILES: CC(=O)[N-]S(=O)(=O)c1ccc(N)cc1.[Na+]
InChIKey: PQMSFAORUFMASU-UHFFFAOYSA-M
Summenformel: C8H9N2NaO3S
Durchschnittliche Molmasse: 236,23 g/mol
Monoisotopische Masse: 236,02315743

Überblick

Sulfacetamide sodium anhydrous is an organic sodium salt that is the monosodium salt of sulfacetamide. It has a role as an antimicrobial agent, an antiinfective agent and an EC 2.5.1.15 (dihydropteroate synthase) inhibitor. It contains a sulfacetamide(1-).

Namen und Bezeichner

Bevorzugter Name: Sodium Sulfacetamide
IUPAC: sodium acetyl-(4-aminophenyl)sulfonylazanide
Lokaler Name: Sulfacetamidnatrium
Englischer Name: Sulfacetamide sodium
Summenformel: C8H10N2O3S.Na
Molmasse: 237.23

Namen und Synonyme

127-56-0Sodium sulfacetamideSulfacetamide sodium anhydrousSulphacetamide sodiumSodium sulfanilylacetamideSodium N-sulfanilylacetamideSulfacetamide sodium saltN-Sulfanilylacetamide, sodium saltSodium sulfacetamide, anhydrousCHEBI:932730760ZE777RefChem:1098858

Weitere Namen anzeigen

SULPHACETAMIDEloculaC08051anteboralbucidefarmamidoctsetanoc-u-mid

204-848-4Sulfacetamide (Sodium)SulfacylumBeocid-isoptalSodium acetyl((4-aminophenyl)sulfonyl)amideMFCD00007885Acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium saltSulfacetamide (sodium monohydrate)

Datenbank-Bezeichner

CAS: 127-56-0
PubChem CID: 4022878
DTXSID: DTXSID40889336
ChEMBL: CHEMBL1200416
ChEBI: CHEBI:9327
UNII: 30760ZE777
EC Number: 204-848-4

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA): 86,6 Å²
H-Brücken-Donoren: 1
H-Brücken-Akzeptoren: 5
Frei drehbare Bindungen: 2
Schwere Atome: 15
Formalladung: 0
Komplexität: 304

Physikochemische Eigenschaften

Schmelzpunkt: 257 °C · 257 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Wasserlöslichkeit: Soluble in water
Löslichkeit: 20 mg/mL; · DMF: 20 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS (pH 7.2): 5 mg/mL
Aggregatzustand: Solid
Farbe: White to Almost white
Merck: 14 · 14,8899
Major Application: pharmaceutical (small molecule)
InChI: InChI=1S/C8H10N2O3S.Na/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;/h2-5H,9H2,1H3,(H,10,11);/q;+1/p-1
InChIKey: PQMSFAORUFMASU-UHFFFAOYSA-M
SMILES: S(=O)(=O)(C1C=CC(N)=CC=1)N([Na])C(=O)C
CAS Datenbank: 127 · 127-56-0
EPA chemische Informationen: Acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium salt (127-56-0)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 4.5% (2 of 44) of reports.

Warning

H315 (93.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 44 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Other Safety InformationIMAP assessments - Acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium salt: Environment tier I assessment

Hazard Classes and CategoriesSkin Irrit. 2 (93.2%)

Sicherheitsdaten

wgk: 3
tsca: TSCA listed
ridadr: 3249
hs_code: 2935.90.9500
RTECS-Nr.: AC8480000
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36
hazard_class: 6.1(b)
packing_group: III
Speicherklasse: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 2 Einträge

SODIUM SULFACETAMIDE

Sulfonamide Antibacterial [EPC]; Sulfonamides [CS]

Verwendung und Herstellung

General Manufacturing InformationAcetamide, N-[(4-aminophenyl)sulfonyl]-, sodium salt (1:1): INACTIVE

Anwendungen · 2 Einträge

BeschreibungSulfacetamide is a sulfonamide antibiotic that is bacteriostatic against Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (IC50 = 9.6 μM), blocking the synthesis of dihydrofolic acid, and also inhibits bacterial 4-aminobenzoic acid , which is required for the synthesis of folic acid.

VerwendenSulfacetamide Sodium is an anti-biotic