Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat

Meclofenamate · ci583 · C02996 · Movens · meclomen · Meclonax · sodiummeclophenamate · SODIUM MECLOFENAMATE

Identifikatoren & physikalische Daten

CAS No.	6385-02-0
Summenformel	C14H10Cl2NO2-
Durchschnittliche Molmasse	295,1 g/mol
Monoisotopische Masse	294,0088589 g/mol
SMILES	Cc1ccc(Cl)c(Nc2ccccc2C(=O)[O-])c1Cl
InChIKey	SBDNJUWAMKYJOX-UHFFFAOYSA-M
PubChem CID	4036
ChEMBL	CHEMBL876
ChEBI	CHEBI:76230
Lokaler Name	Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat

Chemische & physikalische Eigenschaften

XLogP	5,8
Polarare Oberfläche (TPSA)	52,2
H-Brücken-Donoren	1
H-Brücken-Akzeptoren	3
Frei drehbare Bindungen	2
Schwere Atome	19
Formalladung	-1
Komplexität	321
Schmelzpunkt	287-291 °C
Lagerbedingungen	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Aggregatzustand	White solid.
Farbe	White to Off-White
Biologische Quelle	synthetic (organic)
Merck	14,5779
Stabilität	Hygroscopic
Hauptanwendungen	pharmaceutical
InChI	1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
InChIKey	CHGIZYUDGOIAFY-UHFFFAOYSA-N
SMILES	[Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl

Sicherheit & Vorschriften

Wassergefährdungsklasse (WGK)	3
Zollcode	2922498050
RTECS-Nr.	CB2975500
Lagerklasse	11 - Combustible Solids

Anwendungen & Verwendung

Beschreibung

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.

Verwenden

Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.

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HCID 4036Erstellt: 3. November 2026