Quisqualic Acid

HCID 40539CAS 52809-07-1
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

Standard-SMILES
N[C@@H](Cn1oc(=O)[nH]c1=O)C(=O)O
InChIKey
ASNFTDCKZKHJSW-REOHCLBHSA-N
Summenformel
C5H7N3O5
Durchschnittliche Molmasse
189,13 g/mol
Monoisotopische Masse
189,03857032

Überblick

Quisqualic acid is a non-proteinogenic alpha-amino acid.

Namen und Bezeichner

Bevorzugter Name
Quisqualic Acid
IUPAC
(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Englischer Name
Quisqualic acid
Summenformel
C5H7N3O5
Molmasse
189.13

Namen und Synonyme

QUISQUALIC ACID52809-07-1DTXSID208969278OC22C1B991,2,4-Oxadiazolidine-2-propanoic acid, alpha-amino-3,5-dioxo-, (S)-(2S)-2-azaniumyl-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoateRefChem:389258DTXCID601326364QuisqualateL-Quisqualic acid(+)-Quisqualic acid(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Weitere Namen anzeigen
(+)-QuisqualicAci()-QUISQUALIC ACIDL(+)-QUISQUALIC ACIDQuisqualic acid (7CI)QUISQUALIC ACID USP/EP/BP
Quisqualinic acid[3H]quisqualate(S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acidL-quisqualic-acid1mm7MFCD00069337C5H7N3O5CHEMBL168279

Datenbank-Bezeichner

CAS
52809-07-1
PubChem CID
40539
DTXSID
DTXSID20896927
ChEMBL
CHEMBL168279、CHEMBL279956
ChEBI
CHEBI:8734
UNII
8OC22C1B99
EC Number
637-070-2
Nikkaji
J9.726H

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-3,9
Polarare Oberfläche (TPSA)
122 Ų
H-Brücken-Donoren
3
H-Brücken-Akzeptoren
6
Frei drehbare Bindungen
3
Schwere Atome
13

Experimentelle und physikochemische Eigenschaften

DrugsPharmaceuticals -> Listed in ZINC15

Physikochemische Eigenschaften

Schmelzpunkt
185 · 185-187°C dec.
Siedepunkt
324.36 °C · 324.36°C (rough estimate)
Dichte
1.6649 · 1.6649 (rough estimate)
Brechungsindex
1.619 · 1.6190 (estimate)
storage temp.
2 · 2-8°C
Löslichkeit
4 OH · NH4OH 1 M: 20 mg/mL, clear, colorless

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H302+H312+H332 (41.2%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 68 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Sicherheitsdaten

F
10
wgk
3
risk_code
20/21/22
hazard_code
Xn
safety_code
26-36
Speicherklasse
11 - Combustible Solids

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological ClassificationDrugs that bind to and activate excitatory amino acid receptors.
Anwendungen · 2 Einträge

BeschreibungL-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; Ki = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.

VerwendenQuisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.

Anbieter50 Anbieter

湖北万得化工有限公司15377098680 15377098680 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]

Zugehörige Reaktionen

2
Reaktionsaufzeichnung erstellen

Verknüpfte Notizen

Wird geladen…