SEW2871
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Grundinformationen
- CAS
256414-75-2- Standard-SMILES
FC(F)(F)c1cccc(-c2noc(-c3cc(-c4ccccc4)c(C(F)(F)F)s3)n2)c1- InChIKey
OYMNPJXKQVTQTR-UHFFFAOYSA-N- Summenformel
- C20H10F6N2OS
- Durchschnittliche Molmasse
- 440,368 g/mol
- Monoisotopische Masse
- 440,04180326
Namen und Bezeichner
- Bevorzugter Name
- SEW2871
- IUPAC
- 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
- Englischer Name
- 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
- Summenformel
- C20H10F6N2OS
- Molmasse
- 440.36
Namen und Synonyme
SW2871SEW 2871BUTTPARK 82\12-95SEW 2871, S1P1 agonistSEW2871, 10 mM in DMSOS1P? Receptor Agonist, SEW2871SPHINGOSINE-1-PHOSPATE, RECEPTOR S1P1 AGONISTS1P Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem5-[4-Phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
Datenbank-Bezeichner
- CAS
256414-75-2- PubChem CID
- 4077460
- DTXSID
DTXSID80399085- ChEMBL
CHEMBL224720- ChEBI
CHEBI:92283- EC Number
- 636-741-7
- Nikkaji
- J2.289.571K
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 94.5 · 94.5-95.3 °C
- Siedepunkt
- 490.3 · 490.3±55.0 °C(Predicted)
- Dichte
- 1.415 · 1.415±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 17 mg/mL · DMSO: 17 mg/mL
- Aggregatzustand
- solid
- pka
- -3.48 · -3.48±0.43(Predicted)
- Farbe
- white
- InChI
- 1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
- InChIKey
- OYMNPJXKQVTQTR-UHFFFAOYSA-N
- SMILES
- FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 2934999090
- risk_code
- 25
- hazard_code
- T
- safety_code
- 45
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Chemie und Industrie
Anwendungen
BeschreibungSphingosine-1-phosphate receptor 1 (S1P1) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood. Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P3, the receptor responsible for regulation of heart rate. SEW2871 is a selective S1P1 receptor agonist in both human and mouse that is not active at the S1P2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.
Verwenden5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE is used as medicament for treating and/or preventing cardiovascular conditions in patients with Fabry disease.
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杭州品高化工有限公司0571-87658025 · [email protected]
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上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
江苏星科元信息科技有限公司400-605-7200 15335295587 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
武汉凯威斯科技有限公司86-027-67849912 · [email protected]
河南阿尔法化工有限公司
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