Grundinformationen
- Standard-SMILES
CC(=O)O.O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F- InChIKey
RKXNZRPQSOPPRN-UHFFFAOYSA-N- Summenformel
- C19H24F6N2O5
- Durchschnittliche Molmasse
- 474,4 g/mol
- Monoisotopische Masse
- 474,15894119
Überblick
Flecainide acetate is an acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). It has a role as an anti-arrhythmia drug. It contains a flecainide(1+).
Namen und Bezeichner
- Bevorzugter Name
- Flecainide Acetate
- IUPAC
- acetic acid;N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Namen und Synonyme
Flecainide acetate54143-56-5FLECAINIDE MONOACETATER-818R 818DTXSID8020626M8U465Q1WQBenzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetateDTXCID80626CHEBI:5091NSC719273RefChem:56567
Weitere Namen anzeigen
Flecainide Acetate TabletN-((2RS)-Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetateTambocorFlecainide (acetate)MFCD00214290N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetaten-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetateMLS000069675
Datenbank-Bezeichner
- CAS
54143-56-5- PubChem CID
- 41022
- DTXSID
DTXSID8020626- ChEMBL
CHEMBL1200822- ChEBI
CHEBI:5091- UNII
- M8U465Q1WQ
- EC Number
- 258-997-5
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 96,9 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 32
- Formalladung
- 0
- Komplexität
- 531
Experimentelle und physikochemische Eigenschaften
Solubility>71.2 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 47 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationFlecainide acetate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Flecainide acetate
vLess-DILI-concern
7
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
FLECAINIDE ACETATE
Antiarrhythmic [EPC]
FLECAINIDE ACETATE TABLET
Antiarrhythmic [EPC]
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
Zugehörige Reaktionen
5
Verknüpfte Notizen
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