| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 5.4% (3 of 56) of reports.DangerH302+H312+H332 (30.4%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oralacute toxicity, dermalacute toxicity, inhalation]P203, P260, P261, P264, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P308+P316, P317, P318, P319, P321, P330, P362+P364, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 56 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Regulatorische Informationen | Hazard Traits - BioaccumulationEndocrine ToxicityEnvironmental PersistenceHepatotoxicity and Digestive System ToxicityNeurotoxicity2002/2076Substance: MethoxychlorThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| Weitere Sicherheitsinformationen | IMAP assessments - Benzene, 1,1'-(2,2,2-trichloroethylidene)bis[4-methoxy-: Human health tier I assessment |
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| DOT-Kennzeichnung | Class 9 |
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| Brandgefahren | Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride gas may be formed in fire. (USCG, 1999)Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. |
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| Brandpotenzial | The material is a combustible solid, but difficult to ignite. |
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| Gesundheitsgefahren | Toxicity is relatively low. Inhalation or ingestion causes generalized depression. (USCG, 1999) |
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| Gefahrenübersicht | Methoxychlor is a manufactured chemical that does not occur naturally in the environment. Pure methoxychlor is a pale-yellow powder with a slight fruity or musty odor. Methoxychlor is used as an insecticide against flies, mosquitoes, cockroaches, chiggers, and a wide variety of other insects. It is used on agricultural crops and livestock, and in animal feed, barns, grain storage bins, home gardens, and on pets. Methoxychlor is also known as DMDT, Marlate®, or Metox®.Exposure to methoxychlor may occur during its manufacture or use as a pesticide. Information on the acute (short-term) and chronic (long-term) effects of methoxychlor in humans is not available. In an acute oral study in animals, changes in the liver were reported. Dermal contact with methoxychlor is slightly irritating to skin. Chronic oral exposure of animals to methoxychlor has resulted in effects to the liver, kidneys, and nervous system. Reproductive and developmental effects are the primary concern from methoxychlor exposure. Animal studies have reported developmental and reproductive effects, such as abortions, reduced fertility, reduced litter size, and skeletal effects from oral exposure to methoxychlor. EPA has classified methoxychlor as a Group D, not classifiable as to human carcinogenicity. Inhalation studies are not available for methoxychlor. However, oral studies are available and a risk management decision can be made to assume that the hazards resulting from oral exposure may be indicative of that resulting from inhalation exposure.Methoxychlor is classified as practically nontoxic with an LD50 of 5-6 gm/kg in rats. It does not accumulate in tissues of mammals, but is highly toxic to fish. It persists in the soil with a half-life estimate of 120 days. [EXTOXNET] High-dose animal studies show that organochlorine insecticides can cause liver injury. [LaDou, p. 593] No evidence of hepatic injury in humans as the result of environmental contamination. [Zimmerman, p. 414] |
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| DOT-Nummer und Handbuch | 2761 151(organochlorine pesticide, solid, toxic) |
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| Reaktive Gruppe | Ethers |
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| Special Reports | Nat'l Research Council CanadaMethoxychlor: Its Effects on Environmental Quality (1975) NRCC No. 14102DHEW/NCIBioassay of Methoxychlor for Possible Carcinogenicity (1978) Technical Rpt Series No. 35 DHEW Pub No. (NIH) 78-835DHHS/ATSDRToxicological Profile for Methoxychlor (PB/2003/100140) (September 2002). The ATSDR toxicological profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is presented in less detail.U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) on Methoxychlor (72-43-5).[Available from the Substance File List, as of May 11, 2009: http://www.epa.gov/iris/index.html]For more Special Reports (Complete) data for METHOXYCHLOR (6 total), please visit the HSDB record page. |
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| RCRA-Anforderungen | U247As stipulated in 40 CFR 261.33, when methoxychlor, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).D014A solid waste containing methoxychlor may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. |
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| FIFRA-Anforderungen | The Agency has determined that methoxychlor is not eligible for reregistration. Kincaid Enterprises was the source for all technical product for methoxychlor and its last product was canceled in 2003 for non-payment of the annual registration fee. Three registrants hold the remaining end-use product registrations, all of which are suspended. Of these registrants, two with suspended end-use registrations have submitted voluntary cancellation requests, and another registrant's methoxychlor products are being canceled for non-payment of the annual registration maintenance fee.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Methoxychlor is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0249Pesticide type: Insecticide (Acaricide)Registration Standard Date: 12/88Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): methoxychlorData Call-in (DCI) Date(s): 03/03/95, 10/13/95AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner. |
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| Brandbekämpfung | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Use water spray, powder, alcohol-resistant foam, carbon dioxide. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give one or two glasses of water to drink. Refer for medical attention . |
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| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures) |
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| Sichere Lagerung | Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room. |
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| Expositionsschutz und Persönliche Schutzausrüstung | TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].1.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)] |
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| Brandbekämpfungsverfahren | Water, foam, dry chemical, or carbon dioxide.If material is involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)Fire Fighting: Use self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode. |
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| Lagerbedingungen | Storage temperature: ambientStore in cool, dry area away from fire hazard and out of direct sunlight. |
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| Reinigungsverfahren | SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder.Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled ammount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.If methoxychlor is spilled ... ventilate area of spill. Collect spilled material in the most convenient and safe manner and deposit in sealed containers for reclamation. ... Liquid containing methoxychlor should be absorbed in vermiculite, dry sand, earth, or a similar material.Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Use HEPA vacuum or wet method to reduce dust during clean-up. Do not dry sweep. Collect powdered material in the most convenient and safe manner and deposit in sealed containers ... |
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| Freisetung ohne Brand | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
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| Entsorgungsverfahren | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U247 and D014, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.DDD is a potential candidate for incineration by rotary kiln with a temperature range of 820-1600 °C and a residence time of seconds for liquid or gas and hours for solid. /SRP: Control acid mist from exhaust gases./Incineration with scrubbing is the disposal method for methoxychlor. For the disposal of small quantities of methoxychlor and empty bags, burial in non-crop land away from water supplies is the only practical and recommended method. Recommendable methods: Incineration & landfill. |
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| Verschüttetes entsorgen | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. |
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| Preventive Measures | SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Do not contaminate feed, water, or utensils used in handling them. Avoid using it within 2 wk of freshening or during lactation on any animal whose milk is used for human consumption. Do not use on very young animals.Personnel protection: Keep upwind. ... Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.For more Preventive Measures (Complete) data for METHOXYCHLOR (9 total), please visit the HSDB record page. |
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| Toxikologische Informationen | CDC-ATSDR Toxicological Profile |
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| Körperbelastung | Methoxychlor was detected in human maternal blood taken from pregnant women in the Jackson and Mississippi Delta areas, 122 samples, 0-2.5 ppb concn range, 0.70 ppb mean concn(1). Serum methoxychlor levels in 15 subjects living in agricultural areas in Honduras ranged from <0.24 - <4.07 mg/L(2). Methoxychlor was detected in 26.9% of human breast milk samples collected from mothers of 62 boys with cryptorchidism, and 68 healthy boys in Finland and Denmark from 1997 to 2001, with one sample <LOD, and 94 samples <LOQ(3). |
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| Cancer Sites | [in animals: liver & ovarian cancer] |
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| Wechselwirkungen | Genistein (GE) is a prevalent phytoestrogen whose presence in human and animal foods may affect biological actions of synthetic endocrine active compounds. We have previously reported that in utero and lactational exposure to high doses of GE or the endocrine active pesticide methoxychlor (MXC) caused mammary epithelial proliferation in 21-day-old male rats. Combined exposure to GE and MXC resulted in significant feminization of the male mammary glands. The goals of the current study were to evaluate mammary responses to GE and MXC at the adult stage and investigate relevant mechanisms. Following in utero, lactational exposure (through maternal diet), and direct dietary exposure, the inguinal mammary gland of male rats (90 days of age) was found to exhibit significant morphological alterations in the groups treated with GE and/or MXC compared to the control. GE exposure (at 300 and 800 ppm concentrations) caused lobular enlargement and epithelial proliferation, whereas MXC exposure (800 ppm) led to ductal elongation and lobular enlargement. Combining the two treatments caused prominent proliferation of both ducts and alveolisecretory material was seen in readily recognizable alveolar lumens, which are absent in untreated male mammary. We also surveyed gene expression in the mammary tissue using a cDNA microarray and evaluated relevant protein factors. The results indicated that the treatment effects are likely due to interactions between steroid hormone receptor-mediated signals and growth factor-driven cellular pathways. The distinctive responses associated with the GE+MXC combination were likely linked to enhanced actions of insulin-like growth factor 1 and related downstream pathways.A case of combined poisoning due to exposure to an aerosol containing both malathion and methoxychlor is presented. The following unusual features occurred in the course and outcome of the poisoning: slow onset of symptoms and signs, bilateral profound and permanent sensorineural hearing loss, and residual peripheral neuropathies in the extremities. The possible potentiation of the unusually low toxicity of malathion is suggested and discussed.Exposure of rainbow trout orally to 2 levels of dieldrin (0.04 & 0.2 mg), DDT (0.2 & 1 mg), & methoxychlor (0.6 & 3 mg), on alternate days for 14 days, resulted in increased storage of DDT & methoxychlor in the presence of dieldrin. Storage of dieldrin was decreased in the presence of either DDT or methoxychlor. The storage of methoxychlor was decreased in the presence of DDT.When methoxychlor was administered orally to rats previously treated with carbon tetrachloride, DDT-like neurological symptoms were observed. In addition, methoxychlor was found to accumulate in the fat and liver in amounts approximately 15-19 times the levels observed in control animals. Carbon tetrachloride is known to inactivate certain hepatic enzymes (CYPs or cytochrome P450s) which metabolize xenobiotics, thereby increasing their retention. These data suggest that carbon tetrachloride and other chemicals which inhibit the metabolism of methoxychlor may increase the risk of neurotoxicity.In mice receiving 25 mg/kg/day methoxychlor along with 12 mg/kg/day bromfenvinphos for 6 weeks, inflammatory infiltrations of the liver were larger and denser than observed in animals receiving bromfenvinphos alone. Small changes were observed in the kidneys at similar frequencies and severities in both treatment groups. Although it was not investigated in this study, methoxychlor usually does not produce effects of the liver by itself at such low doses. Thus, the results of this study suggest that there may be an interaction between methoxychlor and bromfenvinphos in producing hepatic effects. |
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| Zielorgane | Developmental (effects while organs are developing), Neurological (Nervous System), Neurological (Nervous System), Reproductive (Producing Children)central nervous system, liver, kidneys |
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| Gesundheitliche Auswirkungen | Animal studies show that methoxychlor may affect the reproductive system, causing harm to the ovaries, uterus, and mating cycle in females, and the testes and prostate in males, as well as decreased fertility in both sexes. Methoxychlor exposure may also cause EEG pattern changes. (T10. L167) |
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| Ökotoxizitätswerte | LD50Species: Anas platyrhynchos (Mallard, female, 3-4 months old) oral >2000 mg/kg /Technical grade/Species: Anas platyrhynchos (Mallard duck, male, 3 months old) oral >2000 mg/kg /Technical grade, 88% & 12% related cmpd/LC50Species: Anas platyrhynchos (Mallard, 16 days old) oral greater than 5000 ppm for 5 days (no mortality to 5000 ppm) /Technical grade/Species: Colinus virginianus (Bobwhite quail, 23 days old) oral greater than 5000 ppm for 5 days (no mortality to 5000 ppm) /Technical grade/For more Ecotoxicity Values (Complete) data for METHOXYCHLOR (99 total), please visit the HSDB record page. |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), Koc values from 23,000 to 93,000(2) measured in pond and river sediments, indicate that methoxychlor is expected to be immobile in soil(SRC). Volatilization of methoxychlor from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 2.03X10-7 atm-cu m/mole(3). Methoxychlor is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.2X10-5 mm Hg(4), determined from a fragment constant method. After 100 days incubation in soil, negligible degradation of methoxychlor was observed under aerobic conditions and 73% degradation was observed under anaerobic conditions(5).TERRESTRIAL FATE: The persistence and disappearance (washoff or dryfall) of methoxychlor from mature soybean foliage was investigated in a small field plot study under natural rainfall conditions in 1977 and 1978. Methoxychlor washoff rate was 8 + or - 4% of the amount on plants (prior to rain) per cm of rainfall, regardless of time after application. Total seasonal washoff for 1978 accounted for 33.5% of the applied pesticidehowever, 30.5% of the total loss was removed by washoff on the second day after application. Dryfall or dislodgeable residue accounted for less than 1% of the amt applied. The amt of dryfall was greater in plots entered by workers than in those where entry was avoided.TERRESTRIAL FATE: Methoxychlor is a moderately persistent compound. Residues have been demonstrated to remain in the soil for up to 14 months.AQUATIC FATE: Based on a classification scheme(1), Koc values measured in sediment ranging from 23,000 to 93,000(2), indicate that methoxychlor is expected to adsorb to suspended solids and sediment(SRC). Mass balances in pond, river and wet sand (25% moisture) systems spiked with methoxychlor indicate that 98.6, 97.0, and 92.1%, respectively, of all methoxychlor was retained in the sediment(3). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 2.03X10-7 atm-cu m/mole(5). According to a classification scheme(6), measured BCF values of 138(7) and 8,300(8) in sheepshead minnows and fathead minnows, respectively, suggest the potential for bioconcentration in aquatic organisms is high to very high. Methoxychlor added to sediment-water mixtures was slowly biodegraded under aerobic conditions (half-lives of 115 and 206 days) and rapidly degraded anaerobically with half-lives of <28 days(9). The effect of hydrolysis(10,11) and oxidation(12,13) on the persistence of methoxychlor in the environment is expected to be negligible.For more Environmental Fate (Complete) data for METHOXYCHLOR (7 total), please visit the HSDB record page. |
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| Lebensmitteluntersuchungswerte | Methoxychlor was detected in US Food and Drug Administration (FDA) Total Diet Studies during Oct 1980 to March 1982 in the following amounts: in the adult diet, 1.5% of 324 food composites2 of 27 dairy product samples at a concn of 0.001-0.004 ppm1 of 27 grain and cereal product samples at a concn of 0.002 ppm2 of 27 legume and vegetable samples at a concn of 0.008-0.022 ppm(1). Methoxychlor was detected in an infant diet at 1.8% of 143 composites, 1 of 13 whole milk samples in a trace amount, 2 of 13 other dairy and dairy substitute samples at a concn of 0.014 ppmin a toddler diet, methoxychlor was detected at 2.1% of 143 composites, 1 of 13 whole milk samples in a trace amount, 1 of 13 other dairy and dairy substitutes at a concn of 0.004 ppm, and in 1 of 13 grain and cereal products at a concn of 0.003 ppm(2). In an adult diet, methoxychlor was detected in 2.1% of 240 composite samples taken during Oct 1979 to Sept 1980 (methoxychlor detected in dairy products, meat, fish and poultry)(3). In an infant diet, methoxychlor was detected in 1.8% of 110 food composites (methoxychlor detected in whole milk, other dairy and dairy substitutes)in a toddler diet, methoxychlor was detected in 3.6% of 110 food composites (methoxychlor detected in whole milk, other dairy and dairy substitutes, fruit and fruit juices)(4). In an adult diet, methoxychlor was detected in 0.42% of 240 composite samples taken during Oct 1978 to 1979(5). In an infant diet, methoxychlor was detected in 0.91% of 110 food compositesin a toddler diet, 2.7% of 110 food composites were positive(6).Methoxychlor was detected 50 times in 24 food samples collected from 37 market basket surveys between 1982 and 1991 at an average concn of 0.0162 ug/g(1). Data contributed from 10 state food laboratories (CA, FL, IN, MA, MI, NC, NY, OR, VA, WI) for the FOODCONTAM database indicated that methoxychlor was detected 5 (0.035%) and 13 (0.099%) times in 13,980 food samples collected in fiscal years 1988 and 1989, respectively(2). Methoxychlor was detected in less than 1% of 598 domestic rice samples at a maximum concn of 0.18 ppmrice samples were collected by the US FDA between 1993 and 1994(3). Methoxychlor was detected in strawberries grown in Ontario, Canada, 1983-84(4). During 1971, methoxychlor was detected in 0.4 of 1,803 poultry samples at a concn of 0.01-0.5 ppm (fat basis)(5). Methoxychlor was detected in 38% of food samples in six out of nine collection sites from farms in Gambia and Senegal between May-June 2002 in the following foods (mean concentration in ng/g fresh weight): cabbage (0.4) from BHGcarrot (0.31) from Mboroturnip (2.43), eggplant (10.6), cabbage (9.3), onion (8.61) and tomato (0.07) from Niagalettuce (1.52) and cabbage (0.56) from SGHsweet pepper (0.77), and cabbage (2.37) from Mbaosweet pepper (0.7), tomato (2.96), cabbage (6.85) and eggplant (3.9) from LHG(6). |
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| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
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| Expositionspfade | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.inhalation, ingestionOral (L167)dermal (L167) |
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| Milk Concentrations | ENVIRONMENTAL: Methoxychlor was detected in 6 of 2739 plain milk samples collected by FDA between 1985 and 1991 at a maximum residue of 0.38 ppm(1). Methoxychlor was detected in 26.9% of human breast milk samples collected from mothers of 62 boys with cryptorchidism, and 68 healthy boys in Finland and Denmark from 1997 to 2001, with one sample less than the limit of detection, and 94 samples below the limit of quantification(2).The concentration of methoxychlor in cow milk and plasma were determined following a cutaneous application of a non-commercial emulsion and an iv injection of a solution containing 5 and 1 g methoxychlor, respectively. The max concentration of methoxychlor in milk, found 2 days after dermal administration, was 0.052 ppm, decreased to around 0.005 ppm 30 days later. A distribution volume greater than 200 times the body volume and a dermal absorption of around 1/5 of the topically applied dose were established.Nine lactating Holstein cattle were treated twice at an interval of 14 days with methoxychlor as a 0, 0.25, or 0.5% dermal spray, with 2 quarts of spray mix applied to each animal. Residues of methoxychlor in whole milk were as high as 2.0 and 3.0 ppm in samples from the low and high dosage sprays. Residues dropped rapidly after the first few days so that after 14 days, residues were at most only slightly above the sensitivity limit (0.005 ppm in whole milk) of the analytical method. Transformation of the residue data on whole milk into equiv concn in milk fat indicates that max residues may be expected to be greater than 2.0 and greater than 3.0 ppm in milk fat from cows sprayed with 0.25 and 0.50% methoxychlor.... Residues /were found/ in milk shortly after cows were sprayed with aq suspensions of methoxychlor. Max level of 0.1 mg/L was found 1 day after treatment, and detectable levels persisted for 1 wk. |
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| Luftstandards | Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Methoxychlor is included on this list. |
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| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
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| Clean Water Act Anforderungen | Methoxychlor is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
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| State Drinking Water Standards | (CA) CALIFORNIA 30 ug/L |
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| Landesrichtlinien für Trinkwasser | (AZ) ARIZONA 340 ug/l(ME) MAINE 35 ug/L |
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| Federal Drinking Water Standards | EPA 40 ug/l |
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| Bundesrichtlinien für Trinkwasser | EPA 40 ug/l |
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