| GHS-Einstufung | WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]P203, P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P318, P321, P330, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.3% (6 of 2210) of reports.H302 (96.9%): Harmful if swallowed [Warning Acute toxicity, oral] |
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| Regulatorische Informationen | Chemical: Benzoic acid, 2-hydroxy-, methyl esterChemical: Gaultheria procumbens, ext.Hazard Traits - Fragrance AllergenCommission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Benzoic acid, 2-hydroxy-, methyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzoic acid, 2-hydroxy-, methyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 17-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/2227 |
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| Brandgefahren | This chemical is combustible. (NTP, 1992) |
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| Brandpotenzial | SLIGHT, WHEN EXPOSED TO HEAT OR FLAMECAN REACT WITH OXIDIZING MATERIALS. |
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| Gesundheitsgefahren | Harmful if swallowed, inhaled, absorbed through skin. Vapor mist is irritating to the eyes, mucous membranes, upper respiratory tract and skin. Ingestion of relatively small amount causes severe poisoning and death. Causes nausea, vomiting, acidosis, pulmonary edema, pneumonia, convulsions and death. (USCG, 1999) |
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| Gefahrenübersicht | A skin and eye irritantCan be absorbed through skinMay have CNS adverse effects[ICSC] A skin, eye, mucous membrane, and upper respiratory tract irritant[CAMEO] A skin and eye irritant[eChemPortal: ERMA] Included in list of established contact allergens in humans[EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] An irritantMay cause skin sensitizationEffects in poisoning cases include disturbance of acid-base balance, convulsions, and coma[MSDSonline] See Acetylsalicylic acid. |
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| Reaktive Gruppe | Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters |
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| FIFRA-Anforderungen | Residues of wintergreen oil are exempted from the requirement of a tolerance when used as a attractant in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. |
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| Reactivity Profile | METHYL SALICYLATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This chemical is incompatible with oxidizers. It is also incompatible with strong bases. It may react with iron salts. (NTP, 1992) |
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| Chemical Dangers | Reacts with strong oxidants and strong bases. On combustion, forms toxic fumes. |
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| Air and Water Reactions | Insoluble in water. |
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| NFPA Hazard Classification | 1 - Materials that, under emergency conditions, can cause significant irritation.1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.0 - Materials that in themselves are normally stable, even under fire conditions. |
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| Hazard Classes and Categories | Acute Tox. 4 (97.5%)Acute Tox. 4 (96.9%)Acute toxicity (Oral) - Category 4Repr. 2 |
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| Brandbekämpfung | Fire Extinguishing Agents Not to Be Used: Emits toxic fumes under fire conditions.Use water spray, powder, alcohol-resistant foam, carbon dioxide. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer immediately for medical attention. |
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| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
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| Sichere Lagerung | Separated from strong oxidants and strong bases. |
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| Brandbekämpfungsverfahren | WATER, FOAM, CARBON DIOXIDE, DRY CHEMICAL. |
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| Lagerbedingungen | METHYL SALICYLATE SHOULD BE STORED AND DISPENSED IN TIGHT CONTAINERS. |
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| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
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| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Verschüttetes entsorgen | Personal protection: protective gloves, protective clothing and safety goggles. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
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| Eye Prevention | Wear safety goggles in combination with breathing protection. |
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| Fire Prevention | NO open flames. |
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| Inhalation Risk | No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C. |
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| Wechselwirkungen | ... The prolonged and excessive ingestion of analgesic mixtures containing salicylates in combination with acetaminophen or salicylamide can produce papillary necrosis and interstitial nephritis. /Salicylates/ |
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| Umweltverhalten | TERRESTRIAL FATE: If released on soil, methyl salicylate would readily leach. It would also be expected to partially volatilize from dry soil and photolyze on the soil surface. Based on the results of sceening tests, it would be expected to readily biodregrade. Chemical hydrolysis may be important in alkaline soil. (SRC)AQUATIC FATE: Methyl salicylate is readily biodegradable in screening tests and may be expected to biodegrade in surface waters. Methyl salicylate is expected to hydrolyze in water, the hydrolysis rate increasing with pH. At pH 7.5, its hydrolysis half-life is estimated to be 14.1 days(1,2,SRC). Methyl salicylate will react with singlet oxygen in natural surface waters resulting in a half-life of about 52 hr(3). Methyl salicylate absorbs UV radiation >290 nm and therefore may undergo direct photolysis under environmental conditions. Based on an estimated Henry's Law constant of 9.3X10-7 atm-cu-m/mol(4,5,SRC), a volatilization half-life of 49 days would be expected in a model river(SRC).ATMOSPHERIC FATE: Methyl salicylate reacts with photochemically-produced hydroxyl radicals in the atmosphere resulting in an estimated half-life of 1.4 days(1,SRC). It is fairly soluble in water, 7400 mg/L(2) and may be washed out by rain. |
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| Lebensmitteluntersuchungswerte | Methyl salicylate concentrations of 54 ppm in bakery goods, 840 ppm in candy, 59 ppm in non-alcoholic beverages, 8400 ppm in chewing gum, 27 ppm in ice cream and 200 ppm in syrups. Methyl salicylate has been identified as a volatile component of meat(2).FLAVOR INGREDIENT, METHYL SALICYLATE...NON-ALCOHOLIC BEVERAGES 59 PPMICE CREAM, ICES, ETC 27 PPMCANDY 840 PPMBAKED GOODS 54 PPMCHEWING GUM 8400 PPMSYRUPS 200 PPM. |
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| Unerwünschte Wirkungen | Neurotoxin - Other CNS neurotoxin |
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| Expositionspfade | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
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| Toxizitätsübersicht | The Panel concluded that the following ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment, when formulated to be non-irritating and non-sensitizing, which may be based on a quantitative risk assessment (QRA)...Methyl Salicylate...Safe for use in cosmetics, with qualifications |
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| Signs and Symptoms | Cough. Sore throat.Redness.Nausea. Vomiting. Ringing in the ears. Symptoms may appear if large amounts are accidentally ingested. See Effects of short-term exposure |
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| Effluent Concentrations | In a comprehensive survey of wastewater from 4000 industrial and publicly owned treatment works (POTWs) sponsored by the Effluent Guidelines Division of the U.S. EPA, methyl salicylate was identified in discharges of the following industrial category (positive occurrences, median concn in ppb): organics and plastics (2419), aluminum (3127), electronics (129) and organic chemicals (26.2)(1). The highest effluent concn was 1881 ppb in the organics and plastics industry(1). |
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| ICSC Environmental Data | The substance is harmful to aquatic organisms. |
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| Soil Adsorption/Mobility | The Koc for methyl salicylate estimated from molecular structure is 128(1) and is 33(3,SRC) estimated from its water solubility, 7400 mg/L(2), using a regression equation. According to a suggested classification scheme(4), these low Koc values suggest that methyl salicylate would be highly or very highly mobile in soil(SRC). |
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| Natural Pollution Sources | Methyl salicylate occurs in the leaves of Gaulteria procumbens L. Ericacae, in the bark of Betula lenta L. Betulaceae(1) and in the leaves of Burnum dilitatum(2). It was tentatively identified in emissions from agricultural and natural plant species in the San Joaquin and Sacramento Valley in California(3). |
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| Human Toxicity Excerpts | THE LETHAL DOSE OF METHYL SALICYLATE IS CONSIDERABLY LESS THAN THAT OF SODIUM SALICYLATE. AS LITTLE AS 4 ML (4.7 G) OF METHYL SALICYLATE MAY BE FATAL IN CHILDREN. /METHYL SALICYLATE/Symptoms of poisoning by methyl salicylate differ little from those described for aspirin. Central excitation, intense hyperpnea, and hyperpyrexia are prominent features. The odor of the drug can easily be detected on the breath and in the urine and vomitus. /Methyl salicylate/In reviews of methyl salicylate poisoning, dimness of vision is mentioned as occurring in about 15% of all cases, but the nature of the impairment has been poorly characterized, and the impression is given that it is a manifestation of disturbance of the CNS. /Methyl salicylate/MILD CHRONIC SALICYLATE INTOXICATION IS TERMED SALICYLISM /&/...SYNDROME INCLUDES HEADACHE, DIZZINESS, RINGING IN EARS, DIFFICULTY IN HEARING, DIMNESS OF VISION, MENTAL CONFUSION, LASSITUDE, DROWSINESS, SWEATING, THIRST, HYPERVENTILATION, NAUSEA, VOMITING, & OCCASIONALLY DIARRHEA. /SALICYLATES/For more Human Toxicity Excerpts (Complete) data for METHYL SALICYLATE (15 total), please visit the HSDB record page. |
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| Wassergefährdungsklasse (WGK) | 1 |
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| R-Sätze (R) | 22-36/38 |
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| Gefahrensymbole | Xn |
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| Sicherheitshinweise (S) | 26-36 |
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