HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Muzolimine
Edrul · Muzolimine · BAY-g-2821 · Muzolimina · Muzoliminum · 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one · 3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one · 3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one
Identifikatoren & physikalische Daten
| CAS No. | 55294-15-0 |
|---|---|
| Summenformel | C11H11Cl2N3O |
| Durchschnittliche Molmasse | 272,13 g/mol |
| Monoisotopische Masse | 271,0279174 g/mol |
| SMILES | CC(c1ccc(Cl)c(Cl)c1)N1N=C(N)CC1=O |
| InChIKey | RLWRMIYXDPXIEX-UHFFFAOYSA-N |
| PubChem CID | 41386 |
| ChEMBL | CHEMBL1697760 |
| ChEBI | CHEBI:135124 |
| EC No. | 259-573-2 |
| DTXSID | DTXSID50866476 |
Chemische & physikalische Eigenschaften
| XLogP | 2 |
|---|---|
| Polarare Oberfläche (TPSA) | 58,7 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 17 |
| Formalladung | 0 |
| Komplexität | 348 |
| Schmelzpunkt | 127-129° |
| Siedepunkt | 401.4±55.0 °C(Predicted) |
| Dichte | 1.5374 (rough estimate) |
| Brechungsindex | 1.5500 (estimate) |
| pKa (Säurekonstante) | 3.30±0.50(Predicted) |
| Aggregatzustand | Solid |
| Farbe | Light yellow to yellow |
Sicherheit & Vorschriften
| Toxizität | LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann) |
|---|
Anwendungen & Verwendung
Beschreibung
Muzolimine is a structurally novel, pyrazolone diuretic with a high-ceiling profile. It is somewhat slower in onset than furosemide, but has a more prolonged effect, similar to the thiazides. Muzolimine has been shown to be effective in edema of cardiac, hepatic and renal origin. It also appears to be effective as an antihypertensive agent.
Verwenden
Diuretic; antihypertensive.