Natriummetavanadat

1166 °F (NTP, 1992)

630 °C

Sodium vanadate appears as colorless to yellow crystals or cream colored solid. Melting point 630 °C.

Liquid

Colorless to yellow or cream-colored solid; [Merck Index] Off-white odorless powder; Hygroscopic; [Alfa Aesar MSDS]

This chemical does not meet GHS hazard criteria for 1% (2 of 191) of reports.

Danger

H301 (99%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 191 reports by companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Chemical: Vanadate (VO31-), sodium

Vanadate (VO31-), sodium (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Vanadate (VO31-), sodium (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 27-07-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/10973

SYMPTOMS: Symptoms from dust inhalation may include irritation of the respiratory tract and conjuctivae; fits of dry coughing, rales, acute bronchospasm, hemoptysis and a greenish black discoloration of the tongue. Systemic symptoms may develop, such as anorexia, anemia, nausea, headache, insomnia, nervousness, dizziness, derangement of kidney function, tremor, psychic disturbances and blindness. Symptoms from ingestion include vomiting, excessive salivation and diarrhea; large doses may damage the nervous system causing drowsiness, convulsions and unconsciousness.

Irritating and toxic; [Merck Index] Inhalation of dust may cause respiratory tract and conjunctivae irritation, coughing, acute bronchospasm, hemoptysis, and greenish-black tongue discoloration; Symptoms of systemic toxicity may include anorexia, anemia, dizziness, altered kidney function, and blindness; Ingestion of large doses may cause nervous system injury; [NTP] A skin and strong eye irritant; Harmful by inhalation; Toxic by ingestion; [Alfa Aesar MSDS] See Vanadium pentoxide.

Acute Tox. 3 (99%)

Acute toxicity (Oral) - Category 3

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

0.061 [mg/m3]

0.67 [mg/m3]

19 [mg/m3]

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration. Vanadium is also believed to induce the production of reactive oxygen species. This may damage DNA and also cause oxidative stress, which can damage the reproductive system. Vanadium also inhibits protein tyrosine phosphatases, producing insulin-like effects. (L837, A247, A248, A249, A250, A251)

0.001

HEAST Current

0.01

HEAST Current

7.80e+01

1.20e+03

2.00e+01

4.00e+03

1.00e-03

Volatile

2.30e+02

3.50e+03

6.00e+01

4.00e+03

1.00e-03

Volatile

Vanadium is absorbed mainly via inhalation, though small amounts can be absorbed through the skin and gastrointestional tract. It is rapidly distributed in the plasma, mainly to the kidney, liver, lungs, heart, bone, where it tends to accumulate. With the help of cytochrome P-450 enzymes, it can interconvert between its two oxidation states, vanadyl (V+4) and vanadate (V+5). Both states of vanadium can reversibly bind to transferrin protein in the blood and then be taken up into erythrocytes. Vanadium is excreted mainly in the urine. (L837)

Used in photography, to make inks, and as a catalyst in organic synthesis; [Merck Index] Used to dye fur, inoculate plants, as a mordant and fixer, and as a corrosion inhibitor in gas-scrubbing systems; [NTP]

Photographic Processing [Category: Other]

Miscellaneous Manufacturing

Vanadate (VO31-), sodium (1:1): ACTIVE