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HCID 4167Erstellt: 4. November 2026

Metixen

Trest · Tremonil · Tremaril · Methixene · Methixart · 60 SJ 1977 · Aids-001633 · metixene USP/EP/BP

Identifikatoren & physikalische Daten

CAS No.	4969-02-2
Summenformel	C20H23NS
Durchschnittliche Molmasse	309,5 g/mol
Monoisotopische Masse	309,15512091 g/mol
SMILES	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1
InChIKey	MJFJKKXQDNNUJF-UHFFFAOYSA-N
PubChem CID	4167
ChEMBL	CHEMBL1201342
ChEBI	CHEBI:51024
EC No.	225-610-6
DTXSID	DTXSID1047867
Lokaler Name	Metixen

Chemische & physikalische Eigenschaften

XLogP	4,9
Polarare Oberfläche (TPSA)	28,5
H-Brücken-Donoren	0
H-Brücken-Akzeptoren	2
Frei drehbare Bindungen	2
Schwere Atome	22
Formalladung	0
Komplexität	349
Arzneimittel	Pharmaceuticals
LogP (Verteilungskoeffizient)	4.7
Löslichkeit	Soluble as HCl salt1.02e-04 g/L
Schmelzpunkt	< 25 °C<25 °C
Physical Description	Solid
Siedepunkt	bp0.07 171-175°
Dichte	1.118±0.06 g/cm3(Predicted)
pKa (Säurekonstante)	9.46±0.10(Predicted)
NIST chemische Informationen	Piperidine, 1-methyl-3-(9h-thioxanthen-9-ylmethyl)-(4969-02-2)

Sicherheit & Vorschriften

GHS-Einstufung	WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard Classes and Categories	Acute Tox. 4 (100%)
Expositionspfade	Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Toxizitätsübersicht	Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance.
Signs and Symptoms	Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Carcinogen Classification	No indication of carcinogenicity to humans (not listed by IARC).
Toxizität	LD50 oral in mouse: 430mg/kg

CAS No.

4969-02-2

Summenformel

C20H23NS

Durchschnittliche Molmasse

309,5 g/mol

Monoisotopische Masse

309,15512091 g/mol

SMILES

CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1

InChIKey

MJFJKKXQDNNUJF-UHFFFAOYSA-N

PubChem CID

4167

ChEMBL

CHEMBL1201342

ChEBI

CHEBI:51024

EC No.

225-610-6

DTXSID

DTXSID1047867

Lokaler Name

Metixen

Chemische & physikalische Eigenschaften

XLogP

4,9

Polarare Oberfläche (TPSA)

28,5

H-Brücken-Donoren

H-Brücken-Akzeptoren

Frei drehbare Bindungen

Schwere Atome

Formalladung

Komplexität

349

Arzneimittel

Pharmaceuticals

LogP (Verteilungskoeffizient)

4.7

Löslichkeit

Soluble as HCl salt1.02e-04 g/L

Schmelzpunkt

< 25 °C<25 °C

Physical Description

Solid

Siedepunkt

bp0.07 171-175°

Dichte

1.118±0.06 g/cm3(Predicted)

pKa (Säurekonstante)

9.46±0.10(Predicted)

NIST chemische Informationen

Piperidine, 1-methyl-3-(9h-thioxanthen-9-ylmethyl)-(4969-02-2)

Sicherheit & Vorschriften

GHS-Einstufung

WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard Classes and Categories

Acute Tox. 4 (100%)

Expositionspfade

Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.

Toxizitätsübersicht

Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance.

Signs and Symptoms

Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).

Toxizität

LD50 oral in mouse: 430mg/kg