| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
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| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
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| Wechselwirkungen | ...METOLAZONE...CHEMICALLY & PHARMACOLOGICALLY RELATED TO THIAZIDE DIURETICS & ELEVATE SERUM URATE LEVELS. ...MAY...INTERACT WITH PROBENECID.USE OF THIAZIDE DIURETIC MAY IMPAIR CONTROL OF DIABETES IN PT TREATED...WITH ORAL HYPOGLYCEMIC AGENTS OR INSULIN, BUT ONLY TO LIMITED EXTENT. /THIAZIDE DIURETICS/METOLAZONE...STRUCTURALLY RELATED TO THIAZIDE DIURETICS, CAN CAUSE HYPOKALEMIA, & MAY BE EXPECTED TO INTERACT WITH CARDIAC GLYCOSIDES.THIAZIDES ENHANCE ANTIHYPERTENSIVE ACTION OF GUANETHIDINE... /THIAZIDE DIURETICS/For more Interactions (Complete) data for METOLAZONE (6 total), please visit the HSDB record page. |
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| Unerwünschte Wirkungen | Hyperuricemia is a common adverse effect due to competitive inhibition of uric acid secretion and a decrease in extracellular fluid from diuretic effects. Other fluid and electrolyte imbalances may occur, especially hyponatremia, hypokalemia, and hypomagnesemia. Any electrolyte imbalances must be corrected before starting treatment. Metolazone may impair glucose tolerance, causing hyperglycemia and glycosuria. Diabetic patients should monitor their blood and urine glucose levels while on this therapy. |
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| Toxizitätsübersicht | For diuretics in general, toxic doses are not well established. Chronic use is the most common cause of toxicity, such as hypotension and increased hematocrit due to plasma volume depletion and syncope. Hypokalemia, hyponatremia and reduced renal function, and increased mortality have been reported with the use of metolazone. Sodium levels should be corrected according to serum glucose levels. |
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| Human Toxicity Excerpts | ADVERSE EFFECTS... ANOREXIA, GASTRIC IRRITATION, NAUSEA, VOMITING, CRAMPING, DIARRHEA, JAUNDICE, PANCREATITIS, SIALADENITIS, DIZZINESS, VERTIGO, PARESTHESIAS, HEADACHE, XANTHOPSIA, LEUKOPENIA, AGRANULOCYTOSIS, THROMBOCYTOPENIA, APLASTIC ANEMIA, ORTHOSTATIC HYPOTENSION. /THIAZIDES/ |
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