Minoxidil
Minoxidil Base · pdp · 2,4-diamino-6-piperidinopyrimidine3-n-oxide · minoxidi · Minoxidil powder · 4-pyrimidinediamine,6-(1-piperidinyl)-3-oxide · rogaine · MONOXIDIL
Identifikatoren & physikalische Daten
| CAS No. | 38304-91-5 |
|---|---|
| Summenformel | C9H15N5O |
| Durchschnittliche Molmasse | 209,25 g/mol |
| Monoisotopische Masse | 209,12766012 g/mol |
| SMILES | N=c1nc(N2CCCCC2)cc(N)n1O |
| InChIKey | ZIMGGGWCDYVHOY-UHFFFAOYSA-N |
| PubChem CID | 4201 |
| ChEMBL | CHEMBL1372483 |
| ChEBI | CHEBI:6942 |
| DTXSID | DTXSID301372970 |
| Lokaler Name | Minoxidil |
Chemische & physikalische Eigenschaften
| XLogP | 1,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 88,9 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 15 |
| Formalladung | 0 |
| Komplexität | 329 |
| Schmelzpunkt | 272-274 °C (dec.) (lit.) |
| Siedepunkt | 348.61°C (rough estimate) |
| Dichte | 1.1651 (rough estimate) |
| Brechungsindex | 1.7610 (estimate) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | Slightly soluble in water, soluble in methanol and in propylene glycol.Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol. |
| pKa (Säurekonstante) | 4.61(at 25℃) |
| Aggregatzustand | Solid |
| Farbe | White |
| Merck | 14,6203 |
| BCS Class | 3 |
| Stabilität | Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Kosmetik-Inhaltsstoffe Funktionen | HAIR FIXINGHAIR CONDITIONING |
| InChI | 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2 |
| InChIKey | ZFMITUMMTDLWHR-UHFFFAOYSA-N |
| SMILES | NC1=CC(=NC(=N)N1O)N2CCCCC2 |
| CAS Datenbank | 38304-91-5(CAS DataBase Reference) |
| NIST chemische Informationen | Minoxidil(38304-91-5) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| Zollcode | 29335990 |
| RTECS-Nr. | UV8200000 |
| R-Sätze (R) | 22-36/37/38-26/27/28 |
| Toxizität | LD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra) |
| Gefahrensymbole | Xn,T+ |
| Sicherheitshinweise (S) | 26-36-45-36/37/39-22 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 38304-91-5(Hazardous Substances Data) |
| Gefahrenklasse | Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3 |
Anwendungen & Verwendung
Beschreibung
Minoxidil is a peripheral vasodilator that directly relaxes vascular smooth musculature, thus, lowering systolic and diastolic pressure. Its action is linked to the activation of calcium channels. Open calcium channels cause hyperpolarization of smooth muscle cells, which in turn, reduces the flow of calcium ions into the cell, which is necessary for supporting vascular tonicity. However, when taking minoxidil, tachycardia, elevated renin secretion, and water and sodium ion retention all appear simultaneously with hypotension.
Verwenden
Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels