Monensin, Mononatriumsalz
Coban · RUMENSIN · Coban45 · Sodiummonensin · Monomycin sodium · Monensinsodiumsal · MONENSINSODIUM,USP · Monensin sodium 40%
Identifikatoren & physikalische Daten
| CAS No. | 22373-78-0 |
|---|---|
| Summenformel | C36H62O11 |
| Durchschnittliche Molmasse | 670,9 g/mol |
| Monoisotopische Masse | 670,42921279 g/mol |
| SMILES | CCC1(C2OC(C3OC(O)(CO)C(C)CC3C)CC2C)CCC(C2(C)CCC3(CC(O)C(C)C(C(C)C(OC)C(C)C(=O)O)O3)O2)O1 |
| InChIKey | GAOZTHIDHYLHMS-UHFFFAOYSA-N |
| PubChem CID | 4243 |
| ChEMBL | CHEMBL4788880 |
| DTXSID | DTXSID10860197 |
| Lokaler Name | Monensin, Mononatriumsalz |
Chemische & physikalische Eigenschaften
| XLogP | 4,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 153 |
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 11 |
| Frei drehbare Bindungen | 10 |
| Schwere Atome | 47 |
| Formalladung | 0 |
| Komplexität | 1.110 |
| Schmelzpunkt | 267-269 C |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | Soluble in methanol at 50mg/ml |
| Aggregatzustand | Off-white to beige solid |
| Farbe | White |
| BRN | 4122200 |
| Stabilität | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | XOIQMTLWECTKJL-BEMBKCOJSA-M |
| LogP (Verteilungskoeffizient) | 3.716 (est) |
| EPA chemische Informationen | Monensin, monosodium salt (22373-78-0) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| UN-Transportnummer | UN 3462 6.1/PG 2 |
| Zollcode | 29419090 |
| RTECS-Nr. | JH2830000 |
| R-Sätze (R) | 25-26/27/28 |
| Gefahrensymbole | T,T+ |
| Sicherheitshinweise (S) | 36/37/39-45-22 |
| Gefahrenklasse | 6.1(a)Acute Tox. 2 OralAquatic Chronic 2Eye Irrit. 2STOT RE 2 |
| Verpackungsgruppe | II |
| Lagerklasse | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
Anwendungen & Verwendung
Beschreibung
Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.
Verwenden
Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.