14,15-Ltc4
Daten werden ergänzt – lade die Seite später neu, um den aktuellen Stand zu sehen
Grundinformationen
- CAS
75290-60-7- Standard-SMILES
CCCCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCC(=O)O)SC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O- InChIKey
OBQVBASHEWLKCQ-PKBWNXTMSA-N- Summenformel
- C30H47N3O9S
- Durchschnittliche Molmasse
- 625,8 g/mol
- Monoisotopische Masse
- 625,30330126
Überblick
Eoxin C4 is a leukotriene that is the 14R-(S-glutathionyl),15S-hydroxy derivative of (5Z,8Z,10E,12E)-icosa-7,9,11,14-tetraenoic acid. It has a role as a metabolite. It is an eoxin and a leukotriene. It is functionally related to a glutathione and a (5Z,8Z,10E,12E)-icosatetraenoic acid.
Namen und Bezeichner
- Bevorzugter Name
- 14,15-Ltc4
- IUPAC
- (5Z,8Z,10E,12E,14R,15S)-14-[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-15-hydroxyicosa-5,8,10,12-tetraenoic acid
- Englischer Name
- 14,15-LEUKOTRIENE C4
- Summenformel
- C30H47N3O9S
- Molmasse
- 625.78
Namen und Synonyme
14,15-Leukotriene C4eoxin C414,15-LTC4EXC4CHEBI:63984DTXSID50103210615S-hydroxy,14R-(S-glutathionyl)-5Z,8Z,10E,12E-eicosatetraenoic acidEXC4 cpdRefChem:137071DTXCID30151710875290-60-7N66RU463NK
Weitere Namen anzeigen
OBQVBASHEWLKCQ-PKBWNXTMSA-NGlycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
orb2283708SCHEMBL290536214,15-Leukotriene C4; EXC4LMFA03020031PD020433HY-130429CS-0107827T84522
Datenbank-Bezeichner
- CAS
75290-60-7- PubChem CID
- 42607303
- DTXSID
DTXSID501032106- ChEBI
CHEBI:63984- UNII
- N66RU463NK
- Nikkaji
- J2.621.339H
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 0,5
- Polarare Oberfläche (TPSA)
- 242 Ų
- H-Brücken-Donoren
- 7
- H-Brücken-Akzeptoren
- 11
- Frei drehbare Bindungen
- 25
- Schwere Atome
- 43
- Formalladung
- 0
- Komplexität
- 982
Experimentelle und physikochemische Eigenschaften
LipidsFatty Acyls [FA] -> Eicosanoids [FA03] -> Leukotrienes [FA0302]
Collision Cross Section244.1 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Calculation: Single Field; Dataset: Oxylipins]
Physikochemische Eigenschaften
- Siedepunkt
- 976.847 · 976.847±65.00 °C(Press: 760.00 Torr)(predicted)
- Dichte
- 1.226 · 1.226±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 50 mg/ml; · DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 100 μg/ml
- Aggregatzustand
- Liquid.
- pka
- 2.214 · 2.214±0.10(predicted)
Chemie und Industrie
Anwendungen
BeschreibungLeukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.
Verwenden14,15-Leukotriene C4 is an acute inflammatory mediator.
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…