1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
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Grundinformationen
- CAS
202463-68-1- Standard-SMILES
Cc1c(C(=O)NN2CCOCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(I)cc1- InChIKey
AJFFBPZYXRNAIC-UHFFFAOYSA-N- Summenformel
- C21H19Cl2IN4O2
- Durchschnittliche Molmasse
- 557,219 g/mol
- Monoisotopische Masse
- 555,99297921
Namen und Bezeichner
- Bevorzugter Name
- 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
- IUPAC
- 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide
- Englischer Name
- 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
- Summenformel
- C21H19Cl2IN4O2
- Molmasse
- 557.21
Namen und Synonyme
AM 281CS-1127AM-281 ,99%AM281AM-281AM281, 10 mM in DMSO1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholino-1H-pyrazole-3-carboxamide1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide1H-Pyrazole-3-carboxamide,1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-inhibit,Inhibitor,neurotoxicity,SH-SY5Y,CB1,Cannabinoid Receptor,memory,AM281,AM-281,AM 281
Datenbank-Bezeichner
- CAS
202463-68-1- PubChem CID
- 4302962
- DTXSID
DTXSID601122269- ChEMBL
CHEMBL476833- ChEBI
CHEBI:93039- UNII
- SBP4A4DYH2
- EC Number
- 633-840-7
- Nikkaji
- J1.084.250F
Eigenschaften
Physikochemische Eigenschaften
- Dichte
- 1.7 · 1.70±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 6 mg/mL · DMSO: >6 mg/mL
- Aggregatzustand
- solid
- pka
- 10.76 · 10.76±0.20(Predicted)
- Farbe
- white
- InChI
- 1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
- InChIKey
- AJFFBPZYXRNAIC-UHFFFAOYSA-N
- SMILES
- Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCOCC4
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 2811 6.1/PG 3
- risk_code
- 25-36/37/38
- hazard_code
- T
- safety_code
- 26-36/37/39-45
- Speicherklasse
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- Hazard Classifications
- Acute Tox. 2 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Anwendungen
BeschreibungAM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively). Structurally, it is an analog of the CB1 inverse agonist rimonabant . It has no effect on the vanilloid TRPV1 receptor. AM281 has been used to evaluate the potential effects of compounds at CB1. It has also been used to study the membrane localization and cycling of CB1.
VerwendenAM 281 acts as a potential CB1 selective receptor cannabinoid antagonist.
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