Clorgyline
Grundinformationen
- CAS
17780-72-2- Standard-SMILES
C#CCN(C)CCCOc1ccc(Cl)cc1Cl- InChIKey
BTFHLQRNAMSNLC-UHFFFAOYSA-N- Summenformel
- C13H15Cl2NO
- Durchschnittliche Molmasse
- 272,17 g/mol
- Monoisotopische Masse
- 271,0530695
Überblick
Clorgyline is an aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant. It has a role as an antidepressant and an EC 1.4.3.4 (monoamine oxidase) inhibitor. It is a dichlorobenzene, an aromatic ether, a tertiary amino compound and a terminal acetylenic compound.
Namen und Bezeichner
- Bevorzugter Name
- Clorgyline
- IUPAC
- 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine
- Englischer Name
- CLORGYLINE
- Summenformel
- C13H15Cl2NO
- Molmasse
- 272.17
Namen und Synonyme
ClorgilineCLORGYLINE17780-72-2ChlorgylineClorgilinaClorgilinumM and B 9302M & B 9302N-(3-(2,4-Dichlorophenoxy)propyl)-N-methyl-2-propynylamineM&B 9302LYJ16FZU9QN-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine
Weitere Namen anzeigen
N-[3-(2,4-Dichlorophenoxy)propyl]-N-methyl-2-propyn-1-aminem&b9302mandb9302n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminn-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminN-Methyl-N-[3-(2,4-dichlorophenoxy)propyl]-2-propyne-1-amine3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl-
DTXSID3048445M&B-9302N-[3-(2,4-dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-CHEBI:3763ClorgilinRefChem:127097DTXCID9028419
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 4,2
- Polarare Oberfläche (TPSA)
- 12,5 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 17
- Formalladung
- 0
- Komplexität
- 263
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Listed in ZINC15
SpringerMaterials PropertiesChemical shift
Collision Cross Section156.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Siedepunkt
- 361.3 · 361.3±37.0 °C(Predicted)
- Dichte
- 1.196 · 1.196±0.06 g/cm3(Predicted)
- pka
- 6.98 · 6.98±0.50(Predicted)
- Aggregatzustand
- Liquid
- Farbe
- Colorless to light yellow
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Anbieter16 Anbieter
Aladdin Scientific[email protected]
Hangzhou Sage Chemical Co., Ltd.+86057186818502 13588463833 · [email protected]
湖北魏氏化学试剂股份有限公司027-59102966 18717199209 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
风咏生物（AbMole）021-10000000 13000000000 · [email protected]
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…