HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 439487Erstellt: 26. Oktober 2026
3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbonsäure, (2S-(2 alpha, 3 beta(R*)))
E-64 · L-TRANS-EPOXYSUCCINYL-LEU-4-GUANIDINOBUTYLAMIDE · TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO)BUTANE · E-64 HEMIHYDRATE · E-64 PROTEASE INHIBITOR · e64(proteinaseinhibitor) · E-64, cysteine protease inhibitor · L-TRANS-3-CARBOXYOXIRAN-2-CARBONYL-L-LEUCYLAGMATINE
https://huagongshe.com/de/chemical/439487
Identifikatoren & physikalische Daten
| CAS No. | 66701-25-5 |
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| Summenformel | C15H27N5O5 |
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| Durchschnittliche Molmasse | 357,41 g/mol |
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| Monoisotopische Masse | 357,20121896 g/mol |
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| SMILES | CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(=O)O)C(=O)NCCCCN=C(N)N |
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| InChIKey | LTLYEAJONXGNFG-HBNTYKKESA-N |
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| PubChem CID | 439487 |
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| ChEMBL | CHEMBL1458713 |
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| EC No. | 613-978-4 |
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| DTXSID | DTXSID90985271 |
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| Lokaler Name | 3-(((1-(((4-((Aminoiminomethyl)-amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)oxiran-carbonsäure, (2S-(2 alpha, 3 beta(R*))) |
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Chemische & physikalische Eigenschaften
| XLogP | -0,9 |
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| Polarare Oberfläche (TPSA) | 172 |
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| H-Brücken-Donoren | 5 |
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| H-Brücken-Akzeptoren | 6 |
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| Frei drehbare Bindungen | 11 |
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| Schwere Atome | 25 |
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| Formalladung | 0 |
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| Komplexität | 518 |
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| Schmelzpunkt | >170°C (dec.) |
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| Dichte | 1.44±0.1 g/cm3(Predicted) |
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| Lagerbedingungen | 2-8°C |
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| Löslichkeit | H2O: 20 mg/mL, clear, colorlessSoluble in DMSO (25mg/ml), or water (20mg/ml) |
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| pKa (Säurekonstante) | 3.16±0.40(Predicted) |
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| Aggregatzustand | White solid |
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| Farbe | White or off-white |
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| Biologische Quelle | synthetic (organic) |
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| BRN | 1405664 |
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| Stabilität | Stable for 1 year from date of purchase as supplied. |
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| InChIKey | LTLYEAJONXGNFG-DCAQKATOSA-N |
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| SMILES | O1[C@H](C(N[C@H](C(NCCCCNC(N)=N)=O)CC(C)C)=O)[C@H]1C(O)=O |
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| CAS Datenbank | 66701-25-5(CAS DataBase Reference) |
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Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 75% (3 of 4) of all reports.WarningH371 (25%): May cause damage to organs [Warning Specific target organ toxicity, single exposure]P260, P264, P270, P308+P316, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 4 reports by companies from 2 notifications to the ECHA C&L Inventory. |
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| Hazard Classes and Categories | STOT SE 2 (25%) |
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| F | 10 |
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| Wassergefährdungsklasse (WGK) | 3 |
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| Zollcode | 29252900 |
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| RTECS-Nr. | RR0390000 |
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| Sicherheitshinweise (S) | 22-24/25 |
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| Lagerklasse | 11 - Combustible Solids |
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Anwendungen & Verwendung
Verwenden
It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained