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Kanamycinsulfat
KANAMYCIN MONOSULFATE · KANAMYCIN ACID SULFATE · KANAMYCIN SULPHATE · Kantrex · klebcil · Kanamycin Acid · Kanamycin monosulfate CRS · kano
Identifikatoren & physikalische Daten
| CAS No. | 25389-94-0 |
|---|---|
| Summenformel | C18H38N4O15S |
| Durchschnittliche Molmasse | 582,6 g/mol |
| Monoisotopische Masse | 582,20543769 g/mol |
| SMILES | NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.O=S(=O)(O)O |
| InChIKey | OOYGSFOGFJDDHP-KMCOLRRFSA-N |
| PubChem CID | 441374 |
| ChEMBL | CHEMBL1446 |
| ChEBI | CHEBI:6109 |
| EC No. | 223-347-1 |
| DTXSID | DTXSID1047524 |
| Lokaler Name | Kanamycinsulfat |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 366 |
|---|---|
| H-Brücken-Donoren | 13 |
| H-Brücken-Akzeptoren | 19 |
| Frei drehbare Bindungen | 6 |
| Schwere Atome | 38 |
| Formalladung | 0 |
| Komplexität | 720 |
| Collision Cross Section | 221.1 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Schmelzpunkt | 250°C |
| Dichte | 1.3619 (rough estimate) |
| Brechungsindex | 117.5 ° (C=1, H2O) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.Soluble in water at 10mg/ml |
| Aggregatzustand | powder |
| Farbe | white to off-white |
| Biologische Quelle | Streptomyces kanamyceticus |
| Merck | 14,5281 |
| Hauptanwendungen | pharmaceutical (small molecule) |
| InChIKey | OOYGSFOGFJDDHP-KMCOLRRFSA-N |
| SMILES | OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 1% (1 of 96) of reports.DangerH360 (69.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]H372 (29.2%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]H400 (29.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410 (29.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 96 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 1 of 96 reports by companies.There are 9 notifications provided by 95 of 96 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Hazard Classes and Categories | Repr. 1B (69.8%)STOT RE 1 (29.2%)Aquatic Acute 1 (29.2%)Aquatic Chronic 1 (29.2%)Repr. 1B (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 29419020 |
| RTECS-Nr. | NZ3225030 |
| R-Sätze (R) | 61 |
| Toxizität | LD50 in mice: 20.7 g/kg orally1450 mg/kg i.p. (Zel'tser) |
| Gefahrensymbole | T |
| Sicherheitshinweise (S) | 22-24/25-45-53 |
| Lagerklasse |
Anwendungen & Verwendung
Beschreibung
Kanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.
Verwenden
Kanamycin sulfate is an antibacterial agent similar to neomycin.