Abacavir sulfate
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Grundinformationen
- CAS
188062-50-2- Standard-SMILES
Nc1nc(NC2CC2)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1.Nc1nc(NC2CC2)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1.O=S(=O)(O)O- Summenformel
- C14H20N6O5S
- Durchschnittliche Molmasse
- 384,41 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Abacavir sulfate
- Englischer Name
- Abacavir sulfate
- Summenformel
- C14H20N6O5S
- Molmasse
- 384.41
Namen und Synonyme
ABACAVIR SULPHATEZIAGENAbacavir HemisulfateAbacavir Sulfate RaceMicDRG 0257Hsdb 7154ABC sulfate1592U89 sulfateUnii-J220T4J9Q2bacavir sulfate
Datenbank-Bezeichner
- CAS
188062-50-2、2736655-48-2- PubChem CID
- 441384
- ChEMBL
CHEMBL4303288- ChEBI
CHEBI:2361- UNII
- 1PPL256S5A、J220T4J9Q2
- EC Number
- 620-488-4
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 222 · 222-225°C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: ≥17mg/mL
- Aggregatzustand
- powder
- Farbe
- white to tan
- Wasserlöslichkeit
- 1.68 ug/L · 1.68ug/L(32 ºC)
- BCS Class
- 3 · 3
- InChIKey
- MBFKCGGQTYQTLR-YFYURQRANA-N
- SMILES
- S(O)(O)(=O)=O.N(C1CC1)C1N=C(N)N=C2N([C@H]3C=C[C@@H](CO)C3)C=NC=12 |&1:16,19,r|
- CAS Datenbank
- 188062 · 188062-50-2(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2933595960
- risk_code
- 63-40
- hazard_code
- Xn
- safety_code
- 36/37
- Speicherklasse
- 11 - Combustible Solids
- Giftige Stoffe Daten
- 188062-50-2(Hazardous Substances Data)
- Hazard Classifications
- Carc. 2Eye Irrit. 2Muta. 2Repr. 2Skin Sens. 1
Chemie und Industrie
Anwendungen
BeschreibungAbacavir sulfate was first launched as Ziagen in the US for the treatment of human immunodeficiency virus (HIV) infection, in combination with other antiretroviral drugs. Abacavir is a carbocyclic nucleoside reverse transcriptase inhibitor (nRTI); it is one of the most potent anti-HIV agents to date. In vitro, Abacavir is a potent and selective inhibitor of HIV-1 and HIV-2 replication. Resistance to Abacavir develops more slowly than for other anti-HIV agents. Abacavir is highly synergistic with protease inhibitors such as Amprenavir. In clinical trials for HIV infections in adults, it produced durable suppression in viral load. Combinations with different protease inhibitors such as Nelfinavir, Saquinavir or Indinavir markedly reduced plasma viral load to undetectable levels for at least 48 weeks, and significantly raised CD4+ cell counts in adults with HIV infection, especially nRTI-naive patients. Abacavir has a good oral availability and its penetration into CSF is much more significant than for other anti-HIV drugs. The two major metabolites identified in humans were the 5'-carboxylate and the 5'-glucuronide, mainly excreted via the renal route.
VerwendenAbacavir sulfate is a nucleoside reverse transcriptase inhibitor (NRTI) used for the treatment of HIV-1 infection and anti-AIDS drug. It has been used in the cytotoxicity to test its tumour promoting activity U937 cells.
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