Grundinformationen
- CAS
125-02-0- Standard-SMILES
C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]- InChIKey
VJZLQIPZNBPASX-OJJGEMKLSA-L- Summenformel
- C21H27Na2O8P
- Durchschnittliche Molmasse
- 484,4 g/mol
- Monoisotopische Masse
- 484,12389301
Überblick
Prednisolone sodium phosphate can cause developmental toxicity according to state or federal government labeling requirements.
Namen und Bezeichner
- Bevorzugter Name
- Prednisolone Sodium Phosphate
- IUPAC
- disodium;[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
- Lokaler Name
- Prednisolon-21-(dinatriumphosphat)
- Englischer Name
- Prednisolone phosphate sodium
- Summenformel
- C21H27Na2O8P
- Molmasse
- 484.39
Namen und Synonyme
prednisolone sodium phosphate125-02-0HydeltrasolPediapredPrednisolone phosphate sodiumPhortisolonePrednisolone disodium phosphateMetretonOrapredPredairInflamase FortePredair Forte
Weitere Namen anzeigen
PREDNISONE SODIUM PHOSPHATESODIUM PREDNISOLONE-21-PHOSPHATEPrednisolone sodium phosphate CRSdisodium prednisolone 21-phosphatepredsol
CodelsolInflamaseMillipredPrednesolPredsolanProzorinSolucortOptival
Datenbank-Bezeichner
- CAS
125-02-0- PubChem CID
- 441409
- DTXSID
DTXSID2047480- ChEMBL
CHEMBL1201014- ChEBI
CHEBI:8379- UNII
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 147 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 32
- Formalladung
- 0
- Komplexität
- 878
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsActive Ingredients (Prednisolone Sodium Phosphate) -> FDA Greenbook
Collision Cross Section197.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 197 °C · >197°C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- Freely soluble in water, very slightly soluble in ethanol (96 per cent).
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Merck
- 14 · 14,7721
- Stabilität
- Hygroscopic
- Major Application
- pharmaceutical small molecule
- InChIKey
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 3.3% (3 of 90) of reports.
Warning
H302 (32.2%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P270, P271, P280, P301+P317, P304+P340, P317, P318, P319, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 90 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Hazard Traits - Developmental Toxicity
Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)-: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)-: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (32.2%)
Sicherheitsdaten
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 2937290000
- RTECS-Nr.
- TU4153300
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Repr. 2STOT RE 2
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
PREDNISOLONE SODIUM PHOSPHATE
Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
MeSH Pharmacological Classification
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Verwendung und Herstellung
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing InformationPregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)-: INACTIVE
Anwendungen
BeschreibungPrednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions. It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM). Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone. It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously. In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.
Verwendenantiinflammatory
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