Grundinformationen
- Standard-SMILES
CNC[C@H](O)c1ccc(O)c(O)c1.Cl- InChIKey
ATADHKWKHYVBTJ-FVGYRXGTSA-N- Summenformel
- C9H13NO3.ClH
- Durchschnittliche Molmasse
- 219,66 g/mol
- Monoisotopische Masse
- 219,06622099
Überblick
Crystals. Used medically as a cardiostimulant.
Namen und Bezeichner
- Bevorzugter Name
- (-)-Epinephrine hydrochloride
- IUPAC
- 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol;hydrochloride
Namen und Synonyme
Epinephrine hydrochloride55-31-2Epinephrine HClAdrenaline hydrochlorideAdrenalin chlorideAdrenaline chlorideEpinephrine chloridel-Adrenaline chloridel-Epinephrine chlorideAdrenalin hydrochloridel-Adrenaline hydrochlorideNCI-C55663
Weitere Namen anzeigen
WBB047OO381,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, hydrochloride, (R)-l-1-(3,4-Dihydroxyphenyl)-2-methylamino-1-ethanol hydrochloride1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochlorideBenzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, hydrochloride, (-)-1,2-Benzenediol, 4-((1R)-1-hydroxy-2-(methylamino)ethyl)-, hydrochlorideCHEBI:6213Orostat 8%
Datenbank-Bezeichner
- CAS
55-31-2- PubChem CID
- 441411
- DTXSID
DTXSID1020568- ChEMBL
CHEMBL3183376- UNII
- WBB047OO38
- EC Number
- 200-230-3
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 72,7 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 14
- Formalladung
- 0
- Komplexität
- 154
Experimentelle und physikochemische Eigenschaften
Human DrugsBreast Feeding; Lactation; Milk, Human; Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Antiglaucoma Agents; Bronchodilator Agents; Catecholamines; Mydriatics; Sympathomimetics; Vasoconstrictor Agents
Melting Point315 °F (NTP, 1992)
Physical DescriptionCrystals. Used medically as a cardiostimulant.
Sicherheit und Regulatorisches
Gefahrenhinweise
Regulatory Information1,2-Benzenediol, 4-(1R)-1-hydroxy-2-(methylamino)ethyl-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available, but it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Adverse reactions include restlessness; anxiety; headache; tremor; weakness; dizziness; pallor; respiratory difficulties; palpitation; nausea and vomiting. (NTP, 1992)
Reactive GroupAlcohols and Polyols
Reactivity ProfileEPINEPHRINE HYDROCHLORIDE is readily destroyed by alkalis and oxidizing agents (NTP, 1992).
Air and Water ReactionsWater soluble [Merck].
Sicherheit und Schutzausrüstung
Fire FightingFires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Nonfire Spill Response
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
Toxikologische Informationen
Carcinogen Classification
Epinephrine Hydrochloride
TR-380: Toxicology and Carcinogenesis Studies of l-Epinephrine Hydrochloride (CASRN 55-31-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1990 )
11/20/89
Inadequate Experiment
Inadequate Experiment
Inadequate Experiment
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
EPINEPHRINE HYDROCHLORIDE
Adrenergic beta-Agonists [MoA]; Adrenergic alpha-Agonists [MoA]; Catecholamines [CS]; Catecholamine [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]
MeSH Pharmacological Classification
Drugs that selectively bind to and activate alpha adrenergic receptors.
Drugs that selectively bind to and activate beta-adrenergic receptors.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs used to cause constriction of the blood vessels.
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