HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(+/-)-4-(3-Tert-butylamino-2-hydroxypropoxy)-2-methyl-1(2H)-isoquinolinehydrochloride
N 696 · Selecal · Tilisolol HCl · trade name Selecal · tilisolol hydrochloride · Tilisolol, trade name Selecal · 4-(3-(tert-ButylaMino)-2-hydroxypropoxy)-2-Methylisoquinolin-1(2H)-one hydrochloride · 1(2H)-Isoquinolinone, 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-2-methyl-, monohydrochloride (9CI)
Identifikatoren & physikalische Daten
| CAS No. | 62774-96-3 |
|---|---|
| Summenformel | C17H25ClN2O3 |
| Durchschnittliche Molmasse | 340,8 g/mol |
| Monoisotopische Masse | 340,1553704 g/mol |
| SMILES | Cn1cc(OCC(O)C[NH2+]C(C)(C)C)c2ccccc2c1=O.[Cl-] |
| InChIKey | SGPGESCZOCHFCL-UHFFFAOYSA-N |
| PubChem CID | 44155 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 66,4 |
|---|---|
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 6 |
| Schwere Atome | 23 |
| Formalladung | 0 |
| Komplexität | 428 |
| Schmelzpunkt | 203-205° |
| Lagerbedingungen | Sealed in dry,Room Temperature |
Sicherheit & Vorschriften
| Toxizität | LD50 in male, female mice and rats (mg/kg): 1393, 1290, 145, 188 orally1219, 1245, 176, 169 s.c.578, 557, 39.5, 29.2 i.p.74.3, 104.7, 75.8, 38.1 i.v. (Kawase) |
|---|
Anwendungen & Verwendung
Beschreibung
Tilisolol hydrochloride is a long acting vasodilating beta-blocker useful in the treatment of hypertension and angina. It is also reported to have antiarrhythmic properties. Due to its relatively long half-life, tilisolol hydrochloride is suitable for once a day dosing. It is currently being investigated as an antiglaucoma agent.