HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Delpazolid
CS-2617 · Delpazolid · LCB01-0371 · Delpazolid (LCB01-0371) · Delpazolid, 10 mM in DMSO · Antibiotic,Delpazolid,inhibit,Bacterial,Inhibitor · LCB 01-0371 · LCB-01-0371
Identifikatoren & physikalische Daten
| CAS No. | 1219707-39-7 |
|---|---|
| Summenformel | C14H17FN4O3 |
| Durchschnittliche Molmasse | 308,31 g/mol |
| Monoisotopische Masse | 308,12846858 g/mol |
| SMILES | CN1CCN(c2ccc(N3C[C@H](CO)OC3=O)cc2F)C=N1 |
| InChIKey | QLUWQAFDTNAYPN-LLVKDONJSA-N |
| PubChem CID | 44205191 |
| ChEMBL | CHEMBL1673408 |
Chemische & physikalische Eigenschaften
| XLogP | 0,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 68,6 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 22 |
| Formalladung | 0 |
| Komplexität | 450 |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Siedepunkt | 481.8±55.0 °C(Predicted) |
| Dichte | 1.44±0.1 g/cm3(Predicted) |
| Lagerbedingungen | Store at -20°C |
| Löslichkeit | DMSO:30.0(Max Conc. mg/mL)97.3(Max Conc. mM) |
| Aggregatzustand | A crystalline solid |
| pKa (Säurekonstante) | 14.05±0.10(Predicted) |
| Farbe | White to off-white |
Sicherheit & Vorschriften
| Alarmwort | Warnung |
|---|---|
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
Anwendungen & Verwendung
Beschreibung
Delpazolid is an oxazolidinone antibiotic. It is active against a wide range of Gram-positive bacterial clinical isolates, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCNS), and penicillin-resistant S. pneumoniae (MICs = 0.125-4 μg/ml). Delpazolid increases survival in mouse models of systemic MRSA, E. faecalis, S. pneumoniae, and H. influenzae infection (ED50s = 2.96, 4.53, 2.28, and 9.96 mg/kg, respectively).