N-[2-[[5-Fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
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Grundinformationen
- CAS
1191911-26-8- Standard-SMILES
COc1cc(N2CCOCC2)ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1- InChIKey
XXHHOTZUJIXPJX-UHFFFAOYSA-N- Summenformel
- C22H25FN6O4S
- Durchschnittliche Molmasse
- 488,545 g/mol
- Monoisotopische Masse
- 488,1642025
Namen und Bezeichner
- Bevorzugter Name
- N-[2-[[5-Fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
- Englischer Name
- N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide
- Summenformel
- C22H25FN6O4S
- Molmasse
- 488.54
Namen und Synonyme
CZC-25146CHEMBL2397014LRRK2 Inhibitor IICZC-25146 freebaseCZC-25146, 10 mM in DMSOLRRK2 INHIBITOR IICZC25146CZC 25146N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMideN-(2-((5-fluoro-2-((2-methoxy-4- morpholinophenyl)amino)pyrimidin- 4- yl)amino)phenyl)methanesulfonamideN-(2-((5-fluoro-2-((2-methoxy-4-morpholinylphenyl)amino)pyrimidine-4-yl)amino)phenyl)methylsulfonylamideN-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Datenbank-Bezeichner
- CAS
1191911-26-8- PubChem CID
- 44252884
- DTXSID
DTXSID401382398- ChEMBL
CHEMBL2397014- EC Number
- 802-315-6
- Nikkaji
- J3.759.619A
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 697.4 · 697.4±65.0 °C(Predicted)
- Dichte
- 1.436 · 1.436±0.06 g/cm3(Predicted)
- storage temp.
- 2 · under inert gas (nitrogen or Argon) at 2-8°C
- Löslichkeit
- 24.45 mg/mL · ≥24.45 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- Aggregatzustand
- solid
- pka
- 8.48 · 8.48±0.10(Predicted)
- Farbe
- Pale purple to purple
Chemie und Industrie
Anwendungen
BeschreibungCZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase). It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.
VerwendenCZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons’s disease, and is ATP-competitive.
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