Tosyllysine Chloromethyl Ketone
Grundinformationen
- CAS
2104-86-1- Standard-SMILES
Cc1ccc(S(=O)(=O)NC(CCCCN)C(=O)CCl)cc1- InChIKey
RDFCSSHDJSZMTQ-UHFFFAOYSA-N- Summenformel
- C14H21ClN2O3S
- Durchschnittliche Molmasse
- 332,8 g/mol
- Monoisotopische Masse
- 332,0961414
Überblick
An inhibitor of SERINE ENDOPEPTIDASES. Acts as an alkylating agent and is known to interfere with the translation process.
Namen und Bezeichner
- Bevorzugter Name
- Tosyllysine Chloromethyl Ketone
- IUPAC
- N-(7-amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide
- Englischer Name
- Tosyllysine chloromethyl ketone
- Summenformel
- C14H21ClN2O3S
- Molmasse
- 332.85
Namen und Synonyme
TOSYLLYSINE CHLOROMETHYL KETONE2104-86-1Tosyllysyl chloromethaneChlorotosylamidoaminoheptanoneBenzenesulfonamide, N-(5-amino-1-(chloroacetyl)pentyl)-4-methyl-Chloromethane, TosyllysylChloromethyl Ketone, TosyllysineKetone, Tosyllysine ChloromethylRefChem:190487N-(7-amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamideTosyl-Lys-CMKTosyl-K-CMK
Weitere Namen anzeigen
DTXSID908597212RL9FJ3XSDTosyl-Lys-ChloromethylketoneSCHEMBL200245Benzenesulfonamide, N-[5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-SCHEMBL5470145CHEMBL2316089CK004
Datenbank-Bezeichner
- CAS
2104-86-1- PubChem CID
- 4427
- DTXSID
DTXSID90859721- ChEMBL
CHEMBL2316089- UNII
- 2RL9FJ3XSD
- Nikkaji
- J215.809D
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,8
- Polarare Oberfläche (TPSA)
- 97,6 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 21
- Formalladung
- 0
- Komplexität
- 414
Physikochemische Eigenschaften
- Siedepunkt
- 509.8 · 509.8±60.0 °C(Predicted)
- Dichte
- 1.242 · 1.242±0.06 g/cm3(Predicted)
- pka
- 8.52 · 8.52±0.50(Predicted)
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.
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