N-[N-[N-(N-L-Tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionin

Metenkefalin

HCID 443363CAS 58569-55-4
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

Standard-SMILES
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O
InChIKey
YFGBQHOOROIVKG-FKBYEOEOSA-N
Summenformel
C27H35N5O7S
Durchschnittliche Molmasse
573,7 g/mol
Monoisotopische Masse
573,22571965

Namen und Bezeichner

Bevorzugter Name
Metenkefalin
IUPAC
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
Lokaler Name
N-[N-[N-(N-L-Tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionin
Englischer Name
H-Tyr-Gly-Gly-Phe-Met-OH
Summenformel
C27H35N5O7S
Molmasse
573.66

Namen und Synonyme

MET-enkephalin58569-55-4Methionine enkephalinTyr-Gly-Gly-Phe-Met-OHMETENKEFALINTYR-GLY-GLY-PHE-METLupex(Met5)-enkephalinOpioid growth factorENKEPHALIN, METHIONINE9JEZ9OD3ASPorcine beta-endorphin 1-5
Weitere Namen anzeigen
YGGFMENKEPHALIN MMet-Enkephalie5Met-enkephalinENDORPHIN (1-5)Met-Enkephaline
Sh-pentapeptide-19Inno-105[Met5]-ENKEPHALINopioid growth factor (OGF)Enkephalin-(5-l-methionine)(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acidNSC-374896metencefalina

Datenbank-Bezeichner

CAS
58569-55-4
PubChem CID
443363
DTXSID
DTXSID90974125
ChEMBL
CHEMBL13786
UNII
9JEZ9OD3AS
EC Number
261-335-8
Nikkaji
J246.108K

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-2,1
Polarare Oberfläche (TPSA)
225 Ų
H-Brücken-Donoren
7
H-Brücken-Akzeptoren
9
Frei drehbare Bindungen
16
Schwere Atome
40

Physikochemische Eigenschaften

Schmelzpunkt
174 · 174-177 °C
Siedepunkt
1052.9 · 1052.9±65.0 °C(Predicted)
Dichte
1.324 · 1.324±0.06 g/cm3(Predicted)
storage temp.
-20 °C · Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
Aggregatzustand
powder

Sicherheit und Regulatorisches

Sicherheitsdaten

F
3-10-21
wgk
3
safety_code
22-24/25

Chemie und Industrie

Pharmakologische Informationen

Mechanism of Action · 1 Eintrag

Metenkefalin is an agonist of µ and δ opioid receptors. It also causes immunostimulation at low doses and immunosuppression at higher doses. Metenkefalin can also inhibit the production of aldosterone, deoxycorticosterone, and corticosterone. Unfortunately, the mechanisms by which these effects occur have not been well described in the literature.

Biological Half-LifeThe half life of metenkefalin is 4.2-39 minutes.
MeSH Pharmacological Classification · 1 Eintrag

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.

Absorption, Distribution and ExcretionMetenkefalin reaches a Cmax of 1266.14pg/mL, with a Tmax of 0.16h, and an AUC of 360.64pg\*h/mL.

Anwendungen

VerwendenEndogenous opioid peptide that also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors

Vor- und nachgelagerte Produkte

Nachgelagerte Produkte

Anbieter50 Anbieter

LIDE PHARMACEUTICALS LIMITED+852-55945652 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]
南京昱盛康生物科技有限公司13327808530 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]

Zugehörige Reaktionen

1
Reaktionsaufzeichnung erstellen

Verknüpfte Notizen

Wird geladen…