Grundinformationen
- Standard-SMILES
CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12.Cl- InChIKey
LJBSAUIFGPSHCN-UHFFFAOYSA-N- Summenformel
- C23H28ClN
- Durchschnittliche Molmasse
- 353,9 g/mol
- Monoisotopische Masse
- 353,19102758
Überblick
Butenafine hydrochloride is the hydrochloride salt of butenafine. An inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, it is used for treatment of dermatological fungal infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor and an antifungal drug. It is a hydrochloride and an ammonium salt. It contains a butenafine.
Namen und Bezeichner
- Bevorzugter Name
- Butenafine Hydrochloride
- IUPAC
- 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
Namen und Synonyme
Butenafine hydrochloride101827-46-7Butenafine HCLMentaxVolleyKP-363Mentax-TCN-(p-tert-Butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochlorideDTXSID2048589Lotrimin UltraJock Itch CreamAthletes Foot Ultra
Weitere Namen anzeigen
R8XA2029ZICHEBI:31325Lotrimin Ultra RingwormN-4-tert-Butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochlorideDTXCID20285151-Naphthalenemethanamine, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-, hydrochlorideN-((4-(1,1-Dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochlorideN-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine hydrochloride
Datenbank-Bezeichner
- CAS
101827-46-7- PubChem CID
- 443867
- DTXSID
DTXSID2048589- ChEMBL
CHEMBL1200397- ChEBI
CHEBI:31325- UNII
- R8XA2029ZI
- EC Number
- 642-354-4
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 3,2 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 1
- Frei drehbare Bindungen
- 5
- Schwere Atome
- 25
- Formalladung
- 0
- Komplexität
- 374
Experimentelle und physikochemische Eigenschaften
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antifungal Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
Warning
H312 (97.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
P280, P302+P352, P317, P321, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (97.6%)
Toxikologische Informationen
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
BUTENAFINE HYDROCHLORIDE
Benzylamines [CS]; Benzylamine Antifungal [EPC]
MeSH Pharmacological ClassificationSubstances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Zugehörige Reaktionen
5
Verknüpfte Notizen
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