Capmatinib hydrochloride anhydrous
Grundinformationen
- CAS
1197376-85-4- Standard-SMILES
CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F.Cl.Cl- InChIKey
ZTNPHABKLIJXTL-UHFFFAOYSA-N- Summenformel
- C23H19Cl2FN6O
- Durchschnittliche Molmasse
- 485,3 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Capmatinib hydrochloride anhydrous
- IUPAC
- 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide;dihydrochloride
- Englischer Name
- INCB28060 Dihydrochloride
- Summenformel
- C23H18ClFN6O
- Molmasse
- 448.89
Namen und Synonyme
Capmatinib dihydrochloride1197376-85-4Z0V2EW20JRcapmatinib hydrochloride anhydrous2-fluoro-n-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide dihydrochloride2-fluoro-n-methyl-4-(7-(quinolin-6-ylmethyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide dihydrochlorideRefChem:200061Capmatinib 2HClCapmatinib (dihydrochloride)2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide;dihydrochloride2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide DihydrochlorideBenzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2)
Weitere Namen anzeigen
INCB28060 2HClINCB28060 DihydrochlorideCapmatinib 2HCl, 10 mM in DMSOCapmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice
UNII-Z0V2EW20JRC23H19Cl2FN6OINC-280 2HClorb1303013SCHEMBL1427109ZTNPHABKLIJXTL-UHFFFAOYSA-NHY-13404AMFCD30502991
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 85,1 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 33
- Formalladung
- 0
- Komplexität
- 637
Physikochemische Eigenschaften
- InChI
- InChI=1S/C23H17FN6O.ClH/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20;/h2-9,11-13H,10H2,1H3,(H,25,31);1H
- InChIKey
- JJBXRCLAAKZSNF-UHFFFAOYSA-N
- SMILES
- C(C1C=CC2N=CC=CC=2C=1)C1=CN=C2N=CC(C3C=CC(C(=O)NC)=C(F)C=3)=NN12.Cl
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (33.3%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (33.3%)
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H371
Chemie und Industrie
Anwendungen
BeschreibungINCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.
VerwendenINCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.
Anbieter68 Anbieter
天津欣康佑生物科技有限公司19922659386 19922659386 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
湖北海克斯生化有限公司17362916295; 17362916295 · [email protected]
Nanjing Fred Technology Co., Ltd+86-25-84696168 +86-15380713688 · [email protected]
济南启源生物科技有限公司18766124282; 18766124282 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
InvivoChem中国13549236410 · [email protected]
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