Flosequinan

HCID 4474062CAS 76568-02-0

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Grundinformationen

Standard-SMILES: Cn1cc(S(C)=O)c(=O)c2ccc(F)cc21
InChIKey: UYGONJYYUKVHDD-UHFFFAOYSA-N
Summenformel: C11H10FNO2S
Durchschnittliche Molmasse: 239,27 g/mol
Monoisotopische Masse: 239,04162778

Überblick

Flosequinan is a member of quinolines.

Namen und Bezeichner

Bevorzugter Name: Flosequinan
IUPAC: 7-fluoro-1-methyl-3-methylsulfinylquinolin-4-one
Englischer Name: Flosequinan
Summenformel: C11H10FNO2S
Molmasse: 239.27

Namen und Synonyme

FLOSEQUINAN76568-02-0ManoplaxBTS-49465Flosequinanum4(1H)-Quinolinone, 7-fluoro-1-methyl-3-(methylsulfinyl)-DTXSID10488336NB119DLU7BTS-49-465DTXCID40287597-fluoro-3-methanesulfinyl-1-methyl-1,4-dihydroquinolin-4-one7-fluoro-1-methyl-3-methylsulfinyl-4-quinoline

Weitere Namen anzeigen

FlosequinonFLOSEQUINAN USP/EP/BPFlosequinan, 10 mM in DMSO7-Huom-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone7-Fluoro-1-methyl-3-methylsulfinylquinolin-4(1H)-one7-Fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone

RefChem:599307C01DB017-Fluoro-1-methyl-3-(methylsulfinyl)quinolin-4(1H)-one7-fluoro-1-methyl-3-methylsulfinylquinolin-4-oneBTS 49 465NCGC00183849-017-fluoro-1-methyl-3-methylsulfinyl-4-quinoloneFlosequinanum [Latin]

Datenbank-Bezeichner

CAS: 76568-02-0
PubChem CID: 4474062
DTXSID: DTXSID1048833
ChEMBL: CHEMBL1908307
ChEBI: CHEBI:134972
UNII: 6NB119DLU7
Nikkaji: J22.166J、J592.636J、J594.241A

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 1,1
Polarare Oberfläche (TPSA): 56,6 Å²
H-Brücken-Donoren: 0
H-Brücken-Akzeptoren: 5
Frei drehbare Bindungen: 1
Schwere Atome: 16
Formalladung: 0
Komplexität: 369

Experimentelle und physikochemische Eigenschaften

DrugsPharmaceuticals -> Cardiovascular system -> Cardiac therapy

Physikochemische Eigenschaften

Schmelzpunkt: 226 · 226-228°
Siedepunkt: 423.1 · 423.1±45.0 °C(Predicted)
Dichte: 1.44 · 1.44±0.1 g/cm3(Predicted)
storage temp.: 2 · 2-8°C
pka: -0.51 · -0.51±0.70(Predicted)

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

C - Cardiovascular system

QC - Cardiovascular system

Metabolism/MetabolitesFlosequinan has known human metabolites that include flosequinan sulfone.

MeSH Pharmacological ClassificationDrugs used to cause dilation of the blood vessels.

Anwendungen · 2 Einträge

BeschreibungFlosequinan is a new mixed arteriolar and venous vasodilator useful for the treatment of patients with congestive heart failure with or without ACE inhibitors, but especially in those patients who are intolerant to ACE inhibitors. It does not cause reflex stimulation of the renin-angiotensin or sympathetic nervous system. How flosequinan achieves its direct vasodilating effect is not clear, it is thought to interfere with protein kinase C and the production of inositol triphosphate. Flosequinan is well absorbed orally, and with the relatively long half-life of its sulfone metabolite it is suitable for once a day administration.

VerwendenAntihypertensive (vasodilator).