HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 448043Erstellt: 4. November 2026
H-1152
H1152 · H1152P · H-1152 · H 1152 · (S)-H-1152 dihydrochloride · (S)-H-1152 (hydrochloride) · (s)-4-methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline · (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
https://huagongshe.com/de/chemical/448043
Identifikatoren & physikalische Daten
| CAS No. | 451462-58-1 |
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| Summenformel | C16H21N3O2S |
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| Durchschnittliche Molmasse | 319,4 g/mol |
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| Monoisotopische Masse | 319,13544809 g/mol |
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| SMILES | Cc1cncc2cccc(S(=O)(=O)N3CCCNC[C@@H]3C)c12 |
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| InChIKey | AWDORCFLUJZUQS-ZDUSSCGKSA-N |
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| PubChem CID | 448043 |
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| ChEMBL | CHEMBL406821 |
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| ChEBI | CHEBI:88220 |
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| DTXSID | DTXSID20735620 |
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Chemische & physikalische Eigenschaften
| XLogP | 1,7 |
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| Polarare Oberfläche (TPSA) | 70,7 |
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| H-Brücken-Donoren | 1 |
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| H-Brücken-Akzeptoren | 5 |
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| Frei drehbare Bindungen | 2 |
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| Schwere Atome | 22 |
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| Formalladung | 0 |
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| Komplexität | 476 |
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| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
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| Siedepunkt | 519.6±60.0 °C(Predicted) |
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| Dichte | 1.218±0.06 g/cm3(Predicted) |
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| Lagerbedingungen | Desiccate at +4°C |
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| Löslichkeit | 25℃: DMSO |
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| Aggregatzustand | Powder |
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| pKa (Säurekonstante) | 9.76±0.40(Predicted) |
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| Farbe | Off-white to light yellow |
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Sicherheit & Vorschriften
| Alarmwort | Achtung |
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| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
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Anwendungen & Verwendung
Beschreibung
Rho-associated kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodeling, smooth muscle contraction, and neuronal development. H-1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM). It is a more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM). H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively). It has been used to examine the role of ROCK in such diverse processes as stress fiber assembly, vasoconstriction, as well as spontaneously tonic smooth muscle and neurite extension.
