BIO
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Grundinformationen
- CAS
667463-62-9- Standard-SMILES
O=Nc1c(-c2c(O)[nH]c3cc(Br)ccc23)[nH]c2ccccc12- InChIKey
WFRDXNRAUPBBTO-SQFISAMPSA-N- Summenformel
- C16H10BrN3O2
- Durchschnittliche Molmasse
- 356,17 g/mol
Namen und Bezeichner
- Bevorzugter Name
- BIO
- Englischer Name
- BIO
- Summenformel
- C16H10BrN3O2
- Molmasse
- 356.17
Namen und Synonyme
Z E6BIOCS-1934MLS2052GSK 3 IXMLS 2052BIO (6BIOBIO (SM04554)BIO USP/EP/BPcell-permeable
Datenbank-Bezeichner
- CAS
667463-62-9- PubChem CID
- 448949
- ChEMBL
CHEMBL2178734、CHEMBL243555、CHEMBL355496、CHEMBL409450、CHEMBL5410800- ChEBI
CHEBI:86290- Nikkaji
- J1.982.273G、J3.111.562K
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 300 °C · 300°C(lit.)
- Siedepunkt
- 554.3 · 554.3±50.0 °C(Predicted)
- Dichte
- 1.8 · 1.80±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 5 mg/mL · DMSO: >5 mg/mL
- Aggregatzustand
- solid
- pka
- 9.56 · 9.56±0.20(Predicted)
- Farbe
- dark red
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
- InChI
- 1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
- InChIKey
- WFRDXNRAUPBBTO-SQFISAMPSA-N
- SMILES
- Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29339900
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- Speicherklasse
- 10 - Combustible liquids
Chemie und Industrie
Anwendungen
BeschreibungBIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively). BIO was also tested for its specificity towards many other commonly studied kinases (IC50 ≥10 μM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency in human and mouse embryonic stem cells (ESCs). BIO is reported to maintain self-renewal in human and mouse ESCs as well as induce the differentiation of neonatal cardiomyocytes.
Verwenden6-bromoindirubin-3′-oxime (BIO) has been used:in MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) cell proliferation assayas a medium supplement in embryonic stem cells (ESCs)for the inhibition of glycogen synthase kinase 3 β (GSK-3β) in human dermal papilla cells (hDPCs)
Anbieter100 Anbieter
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
上海麦克林生化科技股份有限公司
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