HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Zeatin
Zeatine · (E)-Zeatin · rans-zeatin · TRANS-ZEATIN · Zeatin (7CI) · (e)-2-buten-1-o · trans-ZEATIN (Z) · Trans-Zeatin HCl
Identifikatoren & physikalische Daten
| CAS No. | 1637-39-4 |
|---|---|
| Summenformel | C10H13N5O |
| Durchschnittliche Molmasse | 219,24 g/mol |
| Monoisotopische Masse | 219,11201006 g/mol |
| SMILES | C/C(=C\CNc1ncnc2nc[nH]c12)CO |
| InChIKey | UZKQTCBAMSWPJD-FARCUNLSSA-N |
| PubChem CID | 449093 |
| ChEMBL | CHEMBL525239 |
| ChEBI | CHEBI:15333 |
| EC No. | 605-343-5 |
| DTXSID | DTXSID9040631 |
Chemische & physikalische Eigenschaften
| XLogP | 0,7 |
|---|---|
| Polarare Oberfläche (TPSA) | 86,7 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 16 |
| Formalladung | 0 |
| Komplexität | 258 |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Color/Form | Crystals from water |
| Schmelzpunkt | 207-208 °C207 °C |
| Physical Description | Solid |
| Siedepunkt | 395.0±52.0 °C(Predicted) |
| Dichte | 1.40±0.1 g/cm3(Predicted) |
| Lagerbedingungen | -20°C |
| Löslichkeit | H2O: soluble |
| Aggregatzustand | powder |
| pKa (Säurekonstante) | 14.77±0.10(Predicted) |
| Farbe | off-white to yellow |
| Merck | 14,10117 |
| BRN | 616241 |
| Hauptanwendungen | agriculture |
| Kosmetik-Inhaltsstoffe Funktionen | SKIN CONDITIONING |
| InChI | InChI=1S/C10H13N5O/c1-7(4-16)2-3-11-9-8-10(13-5-12-8)15-6-14-9/h2,5-6,16H,3-4H2,1H3,(H2,11,12,13,14,15)/b7-2+ |
| InChIKey | UZKQTCBAMSWPJD-FARCUNLSSA-N |
| SMILES | C(O)/C(/C)=C/CNC1=C2C(=NC=N1)NC=N2 |
| CAS Datenbank | 1637-39-4(CAS DataBase Reference) |
| EPA chemische Informationen | Zeatin (1637-39-4) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | trans-Zeatin: Does not have an individual approval but may be used under an appropriate group standard |
| Special Reports | USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Cytokinin p.v EPA 738-R-95-025 (December 1995). Available from the Database Query page at http://www.epa.gov/pesticides/reregistration/status.htm as of February 9, 2009. |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Wechselwirkungen | ... Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 days of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and step-down latency tasks as a check on immediate against cognitive function. The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE activity in the mice... |
| Natural Pollution Sources | Naturally occurring plant growth hormonecytokinin originally isolated from sweet corn kernels, Zea mays L. Gramineae. |
| Antidote and Emergency Treatment | /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/ |
Anwendungen & Verwendung
Beschreibung
trans-Zeatin is a cytokinin plant growth regulator with antioxidant and neuroprotective activities. It binds to the cytokinin receptor Arabidopsis histidine kinase 3 (AHK3) with a KD value of 1.3 nM. trans-Zeatin increases chlorophyll levels in etiolated Cucumus sativus cotyledons in a concentration-dependent manner. It increases callus growth and shoot formation in N. tabacum calluses when used at concentrations of 5 and 50 μM. trans-Zeatin (25-100 μM) reduces production of reactive oxygen species (ROS) induced by amyloid β (25-35) (Aβ25-35) in PC12 cells. It reduces scopolamine-induced spontaneous alternations in the Y-maze, indicating enhanced spatial memory, in mice when administered at doses of 1.5, 3, and 4.5 mg/kg per day.