Nilvadipine
Daten werden ergänzt – lade die Seite später neu, um den aktuellen Stand zu sehen
Grundinformationen
- CAS
75530-68-6- Standard-SMILES
COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1- InChIKey
FAIIFDPAEUKBEP-UHFFFAOYSA-N- Summenformel
- C19H19N3O6
- Durchschnittliche Molmasse
- 385,4 g/mol
- Monoisotopische Masse
- 385,12738533
Namen und Bezeichner
- Bevorzugter Name
- Nilvadipine
- IUPAC
- 3-O-methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Englischer Name
- Nilvadipine
- Summenformel
- C19H19N3O6
- Molmasse
- 385.37
Namen und Synonyme
nilvadipine75530-68-6EscorNivadilNivadipineFR-34235NilvadipinoNivadipFK 235NilvadipinumDl-nilvadipineFK-235
Weitere Namen anzeigen
SKF-fk235ARC029CL 287389BAY-e-6927SKF-102362
SK&F 102,362CL 287,389DTXSID2046624SK&F-102362CL-287389SK&F-102,3620214FUT37JCL-287,389
Datenbank-Bezeichner
- CAS
75530-68-6- PubChem CID
- 4494
- DTXSID
DTXSID2046624- ChEMBL
CHEMBL517427- ChEBI
CHEBI:31911- UNII
- 0214FUT37J
- EC Number
- 805-887-5
- Nikkaji
- J22.253D
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 2,9
- Polarare Oberfläche (TPSA)
- 134 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 6
- Schwere Atome
- 28
- Formalladung
- 0
- Komplexität
- 783
Experimentelle und physikochemische Eigenschaften
Physical DescriptionSolid
Kovats Retention Index2729.22
Physikochemische Eigenschaften
- Schmelzpunkt
- 148 · 148-150°C
- Siedepunkt
- 511.83 °C · 511.83°C (rough estimate)
- Dichte
- 1.3937 · 1.3937 (rough estimate)
- Brechungsindex
- 1.59 · 1.5900 (estimate)
- storage temp.
- 2 · Keep in dark place,Sealed in dry,2-8°C
- Löslichkeit
- 15 mg/mL, · DMSO: soluble15mg/mL, clear
- Aggregatzustand
- powder
- pka
- -0.81 · -0.81±0.70(Predicted)
- Farbe
- white to beige
- Merck
- 14 · 14,6545
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2933.39.9200
- RTECS-Nr.
- US7968300
- risk_code
- 22
- Toxizität
- LD50 oral in rat: 1560mg/kg
- hazard_code
- Xn
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Chemie und Industrie
Pharmakologische Informationen
ATC Code
C - Cardiovascular system；C08 - Calcium channel blockers；C08C - Selective calcium channel blockers with mainly vascular effects；C08CA - Dihydropyridine derivatives；C08CA10 - Nilvadipine
QC - Cardiovascular system；QC08 - Calcium channel blockers；QC08C - Selective calcium channel blockers with mainly vascular effects；QC08CA - Dihydropyridine derivatives；QC08CA10 - Nilvadipine
Pharmacodynamics
Nilvadipine is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nilvadipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Mechanism of Action
Nilvadipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Cellular LocationsMembrane
Verwendung und Herstellung
Zugehörige Reaktionen
7
Notizen zur Verbindung
Wird geladen…